{"id":8517,"date":"2021-12-28T23:57:44","date_gmt":"2021-12-28T15:57:44","guid":{"rendered":"https:\/\/www.cytologics.com.hk\/?p=8517"},"modified":"2024-05-18T16:28:59","modified_gmt":"2024-05-18T08:28:59","slug":"%e7%a0%94%e7%a9%b6%e8%a1%a8%e6%98%8e-nmn-%e6%94%af%e6%8c%81%e7%b2%92%e7%b7%9a%e9%ab%94%e8%a4%87%e8%a3%bd","status":"publish","type":"post","link":"https:\/\/cytologics.com\/sc\/%e7%a0%94%e7%a9%b6%e8%a1%a8%e6%98%8e-nmn-%e6%94%af%e6%8c%81%e7%b2%92%e7%b7%9a%e9%ab%94%e8%a4%87%e8%a3%bd\/","title":{"rendered":"NMN \u80fd\u652f\u6301\u7c92\u7ebf\u4f53\u590d\u5236"},"content":{"rendered":"
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\u5c31\u50cf\u6211\u4eec\u7ec6\u80de\u6838\u4e2d\u7684\u57fa\u56e0\u7ec4\u4e00\u6837\uff0c\u8fd9\u4e9b\u4ea7\u751f\u80fd\u91cf\u7684\u7ed3\u6784\u4e5f\u6709\u81ea\u5df1\u7684 DNA \u96c6\uff0c\u8fd9\u662f\u7c92\u7ebf\u4f53\u529f\u80fd\u7684\u66ff\u4ee3\u6307\u6807\uff0c\u5e76\u4e14\u4e0e\u591a\u79cd\u4e0e\u8870\u8001\u76f8\u5173\u7684\u75be\u75c5\u6709\u5173\u3002<\/h1>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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By Jonathan D. Grinstein, Ph.D.<\/p>

Published: 12:04 p.m. PST Dec 22, 2021 | Updated: 3:54 p.m. PST Dec 28, 2021<\/p>

\u00a0<\/p>

\u91cd\u5927\u4eae\u70b9<\/h3>

\u00a0<\/p>

\u2022\u65e5\u672c\u7814\u7a76\u4eba\u5458\u7814\u7a76\u4e86\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 (NMN) \u5bf9\u4eba\u4f53\u80be\u7ec6\u80de\u7c92\u7ebf\u4f53\u7684\u4f5c\u7528\u3002<\/div>
\u2022\u4f7f\u7528 NMN \u63d0\u9ad8\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 (NAD+) \u6c34\u5e73\u53ef\u80fd\u6709\u52a9\u4e8e\u901a\u8fc7\u589e\u52a0\u7c92\u7ebf\u4f53\u4ee3\u8c22\u6765\u963b\u6b62\u8870\u8001\u3002<\/div>

\u00a0<\/p>

\u6211\u4eec\u7684\u7ec6\u80de\u5305\u542b\u4e0d\u6b62\u4e00\u7ec4 DNA\uff1a\u6211\u4eec\u7ec6\u80de\u6838\u4e2d\u7684\u4e00\u7ec4\u7f16\u7801\u5927\u591a\u6570\u7ec6\u80de\u8fc7\u7a0b\uff0c\u53e6\u4e00\u7ec4\u7f16\u7801\u7ec6\u80de\u7684\u80fd\u91cf\u4ea7\u751f\u7ed3\u6784\uff0c\u79f0\u4e3a\u7c92\u7ebf\u4f53\u3002\u5c31\u50cf\u6bcf\u4e2a\u7ec6\u80de\u6838\u4e2d\u7684 DNA \u4e00\u6837\uff0c\u7c92\u7ebf\u4f53 DNA (mtDNA) \u7684\u590d\u5236\u548c\u5b8c\u6574\u6027\u5bf9\u4e8e\u7ec6\u80de\u7684\u529f\u80fd\u548c\u7e41\u8363\u4ee5\u53ca\u6211\u4eec\u5b9e\u73b0\u5065\u5eb7\u957f\u5bff\u81f3\u5173\u91cd\u8981\u3002\u4f46\u662f\uff0c\u5728\u8870\u8001\u548c\u957f\u5bff\u7684\u80cc\u666f\u4e0b\uff0c\u5173\u4e8e mtDNA \u4e0e\u7c92\u7ebf\u4f53\u7ebf\u4f53\u529f\u80fd\u4e4b\u95f4\u7684\u8054\u7cfb\uff0c\u6211\u4eec\u8fd8\u6709\u5f88\u591a\u4e1c\u897f\u9700\u8981\u4e86\u89e3\u3002\u8fd9\u6837\u505a\u53ef\u4ee5\u4f7f\u6211\u4eec\u80fd\u591f\u52a0\u5f3a\u8fd9\u4e00\u5173\u952e\u7ec6\u80de\u7ed3\u6784\u7684\u6d3b\u52a8\u53ca\u5176\u72ec\u7acb\u9057\u4f20\u786c\u76d8\u7684\u5b8c\u6574\u6027\uff0c\u4ee5\u6539\u5584\u5065\u5eb7\u548c\u5bff\u547d\u3002<\/p>

\u00a0<\/p>

\u65e5\u672c\u4e5d\u5dde\u5927\u5b66\u7684 Kang \u53ca\u5176\u540c\u4e8b\u5728\u5b66\u672f\u671f\u520a\u300a\u751f\u7269\u5316\u5b66\u6742\u5fd7\u300b(The Journal of Biochemistry)\u4e0a\u62a5\u5bfc\u8bf4\uff0c\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 (NMN) \u53ef\u589e\u5f3a mtDNA \u590d\u5236\u3002\u4ee3\u8868\u65e5\u672c\u751f\u5316\u5b66\u4f1a\u64b0\u6587\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u7528 NMN \u4ecb\u5165\u4eba\u7c7b\u80be\u7ec6\u80de\u4f1a\u6fc0\u6d3b\u5e76\u901a\u8fc7\u589e\u52a0\u7c92\u7ebf\u4f53\u7ebf\u4f53\u4e2d DNA\uff08\u6838\u82f7\u9178\uff09\u7684\u6784\u5efa\u5757\u6570\u91cf\uff0c\u540c\u65f6\u51cf\u5c11\u5176\u964d\u89e3\u4ea7\u7269\uff08\u6838\u82f7\uff09\u6765\u63d0\u9ad8 mtDNA \u590d\u5236\u7387\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\u4e86 NMN \u5982\u4f55\u6709\u76ca\u4e8e\u7c92\u7ebf\u4f53\u3001\u65b0\u9648\u4ee3\u8c22\u4ee5\u53ca\u6700\u7ec8\u8870\u8001\u7684\u673a\u5236\u3002<\/p>

\u00a0<\/p>

\u7814\u7a76\u63ed\u793a NAD+ \u5728 mtDNA \u590d\u5236\u4e2d\u7684\u4f5c\u7528<\/h3>

\u00a0<\/p>

\u4e0e\u8bb8\u591a\u6838\u7f16\u7801\u86cb\u767d\u8d28\u5408\u4f5c\uff0cmtDNA \u57fa\u56e0\u5305\u542b\u5bf9\u57fa\u672c\u7ec6\u80de\u8fc7\u7a0b\uff08\u4f8b\u5982\u4ea7\u751f\u80fd\u91cf\uff09\u7ec4\u4ef6\u7684\u6307\u4ee4\u3002\u7c92\u7ebf\u4f53 DNA \u62f7\u8d1d\u6570\u662f\u8861\u91cf\u6bcf\u4e2a\u7ec6\u80de\u7c92\u7ebf\u4f53\u57fa\u56e0\u7ec4\u6570\u91cf\u7684\u6307\u6807\uff0c\u662f\u7c92\u7ebf\u4f53\u529f\u80fd\u7684\u5fae\u521b\u6307\u6807\uff0c\u4e0e\u591a\u79cd\u8870\u8001\u76f8\u5173\u75be\u75c5\u548c\u5168\u56e0\u6b7b\u4ea1\u7387\u6709\u5173\u3002\u7136\u800c\uff0c\u6211\u4eec\u5bf9\u7c92\u7ebf\u4f53\u5185\u7684\u65b0\u9648\u4ee3\u8c22\u5982\u4f55\u5f71\u54cd mtDNA \u7684\u7ef4\u6301\u548c\u590d\u5236\u4ecd\u7136\u77e5\u4e4b\u751a\u5c11\uff0c\u66f4\u4e0d\u7528\u8bf4\u8fd9\u4e9b\u8fc7\u7a0b\u5982\u4f55\u6210\u4e3a\u8870\u8001\u548c\u957f\u5bff\u7684\u57fa\u7840\u3002<\/p>

\u00a0<\/p>

\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\uff0cKang \u53ca\u5176\u540c\u4e8b\u521b\u5efa\u4e86\u4e00\u79cd\u6d4b\u91cf\u7c92\u7ebf\u4f53\u5185\u4ee3\u8c22\u7684\u65b0\u65b9\u6cd5\uff0c\u4ed6\u4eec\u79f0\u4e4b\u4e3a SLO\uff0c\u4f7f\u4ed6\u4eec\u80fd\u591f\u4e86\u89e3\u7c92\u7ebf\u4f53\u4ee3\u8c22\u5982\u4f55\u8c03\u8282 mtDNA \u590d\u5236\u3002\u4e3a\u6b64\uff0c\u65e5\u672c\u7814\u7a76\u56e2\u961f\u4f7f\u7528\u57fa\u56e0\u64cd\u4f5c\u6765\u63a7\u5236\u79f0\u4e3a\u201ctwinkle\u201d\u7684 mtDNA \u590d\u5236\u673a\u5236\u7684\u6c34\u5e73\uff0c\u636e\u62a5\u5bfc\uff0c\u5b83\u53ef\u4ee5\u6fc0\u6d3b mtDNA \u590d\u5236\u5e76\u589e\u52a0 mtDNA \u62f7\u8d1d\u6570\u3002<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\"Log<\/figure>

(Kang et al., 2021 | Journal of Biochemistry) \u7c92\u7ebf\u4f53\u7684DNA \u590d\u5236\u4f1a\u6539\u53d8\u6838\u82f7\u9178\u548c NAD+ \u7684\u6c34\u5e73\u3002\u8be5\u56fe\u663e\u793a\u4e86\u5728\u7ebf\u7c92\u4f53 DNA (mtDNA) \u590d\u5236\u901a\u8fc7\u79f0\u4e3a Twinkle \u7684\u57fa\u56e0\u53d7\u63a7\u6fc0\u6d3b\u671f\u95f4\u4ee3\u8c22\u7269\u7684\u6c34\u5e73\u5982\u4f55\u53d8\u5316\u3002\u8fd9\u4e9b\u7ed3\u679c\u4e2d\u4e00\u4e9b\u503c\u5f97\u6ce8\u610f\u7684\u6838\u82f7\u9178\u4ee3\u8c22\u7269\u4e0e\u817a\u82f7 (AMP\u3001ADP) \u548c\u5c3f\u82f7 (UTP\u3001UDP) \u4ee5\u53ca\u78f7\u9178\u6838\u7cd6\u4e8c\u78f7\u9178 (PRPP) \u76f8\u5173\uff0c\u8fd9\u5bf9\u4e8e\u6838\u82f7\u9178\u7684\u4ea7\u751f\u81f3\u5173\u91cd\u8981\u3002\u7ea2\u8272\uff0c\u5927\u7684\u663e\u8457\u53d8\u5316\uff1b \u84dd\u8272\uff0c\u5c0f\u7684\u663e\u8457\u53d8\u5316\uff1b \u7eff\u8272\uff0c\u53d8\u5316\u4e0d\u5927\uff1b \u9ed1\u8272\uff0c\u6ca1\u6709\u53d8\u5316\u3002\n<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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NMN \u8c03\u8282\u7c92\u7ebf\u4f53\u590d\u5236\u6fc0\u6d3b<\/h3>

\u00a0<\/p>

Kang \u53ca\u5176\u540c\u4e8b\u968f\u540e\u68c0\u67e5\u4e86 mtDNA \u590d\u5236\u4e0e NAD+ \u4e4b\u95f4\u5173\u7cfb\u7684\u6027\u8d28\u3002\u4e3a\u4e86\u8bc1\u660e NAD+ \u5bf9 mtDNA \u4ea7\u751f\u56e0\u679c\u5f71\u54cd\uff0c\u800c\u4e0d\u4ec5\u4ec5\u662f\u76f8\u5173\u6027\uff0c\u7814\u7a76\u4eba\u5458\u8fde\u7eed\u4e09\u5929\u7528 NMN\uff08NAD+ \u7684\u524d\u4f53\uff09\u4ecb\u5165\u4eba\u7c7b\u80be\u7ec6\u80de\uff0c\u7136\u540e\u91cf\u5316 mtDNA \u7684\u6570\u91cf\u3002\u5728 NMN \u5904\u7406\u7684\u7ec6\u80de\u4e2d\uff0c\u901a\u8fc7\u63a7\u5236\u6267\u884c\u8fd9\u79cd mtDNA \u590d\u5236\u8fc7\u7a0b\u7684\u201cTwinkle\u201d\u86cb\u767d\uff0cmtDNA \u7684\u6570\u91cf\u589e\u52a0\u5230\u4e0e\u6fc0\u6d3b mtDNA \u590d\u5236\u7684\u6761\u4ef6\u76f8\u5f53\u7684\u6c34\u5e73\u3002\u5728\u786e\u5b9a NMN\u7684\u4ecb\u5165\u53ef\u4ee5\u589e\u52a0 mtDNA \u7684\u6570\u91cf\u540e\uff0cKang \u53ca\u5176\u540c\u4e8b\u8868\u660e\uff0cNMN \u4e5f\u589e\u52a0\u4e86 mtDNA \u590d\u5236\u7684\u901f\u5ea6\u3002\u7ed3\u5408 NMN \u7ba1\u7406\u548c\u77ac\u95f4\u6fc0\u6d3b(twinkly activation)\u589e\u5f3a\u4e86\u5bf9 mtDNA \u590d\u5236\u548c\u62f7\u8d1d\u6570\u7684\u6709\u76ca\u5f71\u54cd\u3002<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\"mtDNA\"<\/figure>

(Kang et al., 2021 | Journal of Biochemistry) NMN \u589e\u5f3a mtDNA \u590d\u5236\u3002 Kang \u53ca\u5176\u540c\u4e8b\u6bd4\u8f83\u4e86\u7c92\u7ebf\u4f53 DNA \u6570\u91cf\uff08mtDNA \u62f7\u8d1d\u6570\uff09\u5728 mtDNA \u590d\u5236\u86cb\u767d\u95ea\u70c1\u88ab\u6fc0\u6d3b (DOX)\u3001\u65bd\u7528 NMN \u4ee5\u53ca\u8fd9\u4e24\u8005\u7684\u7ec4\u5408\u7684\u6761\u4ef6\u4e0b\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u76f8\u5bf9\u4e8e\u672a\u7ecf\u5904\u7406\u7684\u7ec6\u80de\uff0c\u6240\u6709\u6761\u4ef6\u90fd\u663e\u793a\u51fa mtDNA \u6570\u91cf\u7684\u589e\u52a0\u3002\u95ea\u70c1\u6fc0\u6d3b(twinkly activation)\u4e0e NMN \u7684\u4f5c\u7528\u5177\u6709\u7efc\u5408\u6548\u679c\u3002\n<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Kang \u53ca\u5176\u540c\u4e8b\u901a\u8fc7\u8ba8\u8bba\u8fd9\u4e9b\u6570\u636e\u5982\u4f55\u8868\u660e NMN \u548c mtDNA \u590d\u5236\u901a\u8fc7\u6838\u82f7\u9178\u6c60\u5408\u6210\u7684\u8c03\u8282\u5728\u529f\u80fd\u4e0a\u76f8\u5173\u8054\u6765\u7ed3\u675f\u8fd9\u7bc7\u6587\u7ae0\u3002\u4ed6\u4eec\u8868\u793a\u4ed6\u4eec\u6b63\u5728\u8fdb\u4e00\u6b65\u8c03\u67e5\u8fd9\u4e2a\u95ee\u9898\u4ee5\u6f84\u6e05\u6f5c\u5728\u7684\u673a\u5236\u3002<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\u53c2\u8003\u6587\u732e:<\/p>

\u00a0<\/p>

Nomiyama T, Setoyama D, Yasukawa T, Kang D. Mitochondria Metabolomics Reveals a Role of \u03b2-Nicotinamide Mononucleotide Metabolism in Mitochondrial DNA Replication. J Biochem. 2021 Dec 4:mvab136. doi: 10.1093\/jb\/mvab136. Epub ahead of print. PMID: 34865026<\/p>

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\u6587\u7ae0\u6765\u6e90:<\/p>

\u00a0<\/p>

https:\/\/www.nmn.com\/news\/nmn-enhances-mitochondrial-genome-replication-in-human-cells<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

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