{"id":9259,"date":"2021-04-30T01:03:29","date_gmt":"2021-04-29T17:03:29","guid":{"rendered":"https:\/\/www.cytologics.com.hk\/?p=9259"},"modified":"2024-05-18T16:00:56","modified_gmt":"2024-05-18T08:00:56","slug":"nmn%e6%b8%9b%e8%bc%95%e9%a6%99%e7%85%99%e8%aa%98%e7%99%bc%e7%9a%84%e8%82%ba%e7%ba%96%e7%b6%ad%e5%8c%96%e4%b8%ad%e7%9a%84%e8%82%ba%e6%90%8d%e5%82%b7","status":"publish","type":"post","link":"https:\/\/cytologics.com\/sc\/nmn%e6%b8%9b%e8%bc%95%e9%a6%99%e7%85%99%e8%aa%98%e7%99%bc%e7%9a%84%e8%82%ba%e7%ba%96%e7%b6%ad%e5%8c%96%e4%b8%ad%e7%9a%84%e8%82%ba%e6%90%8d%e5%82%b7\/","title":{"rendered":"NMN\u51cf\u8f7b\u9999\u70df\u8bf1\u53d1\u7684\u80ba\u7ea4\u7ef4\u5316\u4e2d\u7684\u80ba\u635f\u4f24"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"9259\" class=\"elementor elementor-9259\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"gap-default elementor-section elementor-top-section elementor-element elementor-element-27c3e5a6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"27c3e5a6\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-393f0668\" data-id=\"393f0668\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6935219 elementor-widget elementor-widget-text-editor\" data-id=\"6935219\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h1>\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178\uff08NMN\uff09\u6e05\u9664\u9999\u70df\u70df\u96fe\u4e2d\u8001\u5316\u7684\u975e\u589e\u6b96\u80ba\u7ec6\u80de\u3002<\/h1>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-705d2d0e elementor-widget elementor-widget-text-editor\" data-id=\"705d2d0e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>By Brett J. Weiss<\/p><p>Published: 4:25 p.m. PST Feb 26, 2021 | Updated: 9:03 am PST Apr 30, 2021<\/p><p>\u00a0<\/p><h3>\u91cd\u5927\u4eae\u70b9<\/h3><p>\u00a0<\/p><div>\u2022NMN\u4ecb\u5165\u53ef\u6062\u590d\u53d7\u635f\u7684\u7ec6\u80de\u51c0\u5316\u8fc7\u7a0b\uff0c\u4ee5\u9632\u6b62\u63a5\u89e6\u9999\u70df\u70df\u96fe\u540e\u8001\u5316\u3001\u975e\u589e\u6b96\u7684\u7ec6\u80de\u5806\u79ef\u3002<\/div><div>\u2022\u51cf\u8f7b\u8fd9\u4e9b\u7ec6\u80de\u7684\u5806\u79ef\u53ef\u9632\u6b62\u81f4\u547d\u6027\u75be\u75c5\u80ba\u7ea4\u7ef4\u5316\u7684\u53d1\u5c55\u3002<\/div><div>\u00a0<\/div><p>\u6211\u4eec\u90fd\u77e5\u9053\u5438\u70df\u6709\u5bb3\u5065\u5eb7\u3002\u8fd9\u4e5f\u662f\u5bfc\u81f4\u7279\u53d1\u6027\u80ba\u7ea4\u7ef4\u5316\uff08IPF\uff09\u7684\u4e3b\u8981\u539f\u56e0\uff0cIPF\u662f\u4e00\u79cd\u81f4\u547d\u7684\u3001\u4e0e\u5e74\u9f84\u6709\u5173\u7684\u81f4\u547d\u6027\u80ba\u90e8\u75be\u75c5\uff0c\u6e90\u4e8e\u80ba\u7ec4\u7ec7\u7622\u75d5\u5f62\u6210\u3002\u4eba\u4eec\u5bf9IPF\u7684\u53d1\u5c55\u6240\u77e5\u751a\u5c11\uff0c\u4f46\u6211\u4eec\u786e\u5b9e\u77e5\u9053\uff0c\u9999\u70df\u70df\u96fe\u4e0e\u8870\u8001\u7684\u975e\u589e\u6b96\u7ec6\u80de\uff08\u7814\u7a76\u4eba\u5458\u79f0\u4e3a\u8870\u8001\u7ec6\u80de\uff09\u7684\u79ef\u7d2f\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u4fc3\u6210\u56e0\u7d20\u3002\u4f46\u662f\uff0c\u5173\u4e8e\u9999\u70df\u70df\u96fe\u5982\u4f55\u4e0e\u8870\u8001\u7ec6\u80de\u7684\u5f62\u6210\u8054\u7cfb\uff0c\u4ee5\u53ca\u5982\u4f55\u51cf\u7f13IPF\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u8fdb\u5c55\uff0c\u8fd8\u6709\u66f4\u591a\u7684\u673a\u5236\u6709\u5f85\u7814\u7a76\u3002<\/p><p>\u00a0<\/p><p>\u6765\u81ea\u4e2d\u56fd\u5357\u65b9\u533b\u79d1\u5927\u5b66\u7684Zhang\u548c\u540c\u4e8b\u5728\u5b66\u672f\u671f\u520a\u300a\u81ea\u7531\u57fa\u751f\u7269\u5b66\u548c\u533b\u5b66\u300b(Free Radical Biology and Medicine)\u4e0a\u53d1\u8868\u4e86\u4e00\u9879\u7814\u7a76\uff0c\u4ed6\u4eec\u53d1\u73b0\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178\uff08NMN\uff09\u7684\u4ecb\u5165\u53ef\u523a\u6fc0\u63a5\u89e6\u9999\u70df\u70df\u96fe\u7684\u5c0f\u9f20\u8870\u8001\u7ec6\u80de\u7684\u53d7\u635f\u7ec6\u80de\u6e05\u6d01-\u81ea\u566c\u4f5c\u7528\u3002\u8be5\u7814\u7a76\u5c0f\u7ec4\u53d1\u73b0\u4e86\u4e00\u79cd\u9014\u5f84\uff0c\u901a\u8fc7\u8fd9\u79cd\u9014\u5f84\uff0c\u9999\u70df\u70df\u96fe\u53ef\u4fc3\u4f7f\u6709\u5bb3\u7684\u542b\u6c27\u5206\u5b50\u5728\u7ec6\u80de\u7684\u53d1\u7535\u7ed3\u6784\u7c92\u7ebf\u4f53\u4e2d\u79ef\u805a\uff0c\u79f0\u4e3a\u6d3b\u6027\u6c27\uff08ROS\uff09\uff0c\u4ee5\u4fc3\u8fdb\u8870\u8001\u7ec6\u80de\u7684\u79ef\u805a\u3002\u8be5\u7c92\u7ebf\u4f53ROS\u53ef\u4ee5\u901a\u8fc7NMN\u523a\u6fc0\u7684\u81ea\u566c\u53bb\u9664\uff0c\u4ee5\u51cf\u8f7b\u7ec6\u80de\u8870\u8001\u548c\u968f\u540e\u7684IPF\u3002\u5982\u679c\u8fd9\u4e9b\u7ed3\u679c\u53ef\u8f6c\u5316\u4e3a\u4eba\u7c7b\uff0c\u5219NMN\u53ef\u4ee5\u63d0\u4f9b\u4e00\u79cd\u907f\u514dIPF\u7684\u65b9\u6cd5\uff0c\u5c24\u5176\u662f\u5728\u5438\u70df\u7684\u6210\u5e74\u4eba\u4e2d\u3002<\/p><p>\u00a0<\/p><h3>\u9999\u70df\u70df\u96fe\u8bf1\u5bfc\u80ba\u7ec6\u80de\u8870\u8001<\/h3><p>\u00a0<\/p><p>\u4e3a\u4e86\u6d4b\u8bd5\u9999\u70df\u70df\u96fe\u5bf9\u7ec6\u80de\u8870\u8001\u7684\u5f71\u54cd\uff0cZhang\u548c\u540c\u4e8b\u5c06\u5c0f\u9f20\u653e\u7f6e\u5728\u4e00\u4e2a\u7a7a\u95f4\uff0c\u6bcf\u5929\u4ece\u4e94\u652f\u9999\u70df\u4e2d\u5438\u5165\u9999\u70df\u7684\u70df\u96fe\u4e24\u6b21\uff0c\u6bcf\u6b2130\u5206\u949f\uff0c\u6301\u7eed\u56db\u4e2a\u661f\u671f\u3002\u901a\u8fc7\u8fd9\u6837\u505a\uff0c\u4ed6\u4eec\u53d1\u73b0\u9999\u70df\u70df\u96fe\u4f1a\u8bf1\u5bfc\u80ba\u7ec6\u80de\u8870\u8001\u3002\u4ed6\u4eec\u8fd8\u53d1\u73b0\uff0c\u5728\u5b9e\u9a8c\u5ba4\u7528\u7897\u789f\u4e2d\uff0c\u7528\u9999\u70df\u70df\u96fe\u63d0\u53d6\u7269\uff08CSE\uff09\u5904\u7406\u7684\u80ba\u7ec6\u80de\u8870\u8001\u589e\u52a0\u3002\u8fd9\u4e9b\u7ed3\u679c\u5f3a\u70c8\u663e\u793a\u9999\u70df\u70df\u96fe\u8bf1\u5bfc\u80ba\u7ec6\u80de\u8870\u8001\u3002<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a4cfe8e elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"a4cfe8e\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img fetchpriority=\"high\" decoding=\"async\" width=\"560\" height=\"554\" src=\"https:\/\/cytologics.com\/wp-content\/uploads\/2021\/04\/366171_983159.webp\" class=\"attachment-full size-full wp-image-9263\" alt=\"NMN\u6e1b\u8f15\u9999\u7159\u8a98\u767c\u7684\u80ba\u7e96\u7dad\u5316\u4e2d\u7684\u80ba\u640d\u50b7\" \/><\/figure><div class=\"elementor-image-box-content\"><p class=\"elementor-image-box-description\">(Zhang et al., 2021 | Free Radical Biology and Medicine)\u9999\u70df\u70df\u96fe\u66b4\u9732\u8bf1\u5bfc\u8001\u5316\u7684\u975e\u589e\u6b96\u7ec6\u80de\u79ef\u805a\u3002 \u03b2-\u534a\u4e73\u7cd6\u82f7\u9176\u67d3\u8272\u8001\u5316\uff0c\u975e\u589e\u6b96\uff08\u8870\u8001\uff09\u7ec6\u80de\u3002\u4e0a\u9762\u7684\u56fe\u7247\u663e\u793a\u4e86\u5c0f\u9f20\u80ba\u7ec4\u7ec7\u4e2d\u7684\u8870\u8001\u7ec6\u80de\u5448\u84dd\u8272\u3002\u9999\u70df\u70df\u96fe\u66b4\u9732\u7684\u80ba\u7ec4\u7ec7\uff08CS\uff09\u663e\u793a\u51fa\u66f4\u591a\u7684\u84dd\u8272\uff0c\u03b2-\u534a\u4e73\u7cd6\u82f7\u9176\u67d3\u8272\u8f83\u80ba\u7ec4\u7ec7\u672a\u66b4\u9732\u4e8e\u9999\u70df\u70df\u96fe\uff08\u5bf9\u7167\u7ec4\uff09\u3002\u4e0b\u90e8\u5f71\u50cf\u663e\u793a\u80ba\u7ec4\u7ec7\u4e2d\u6709\u8870\u8001\u7ec6\u80de\u6807\u8bb0\u7269p21\u548cp16\u3002\u5728\u8fd9\u4e24\u79cd\u60c5\u51b5\u4e0b\uff0cCS\u80ba\u7ec4\u7ec7\u663e\u793a\u51fa\u6bd4\u672a\u66b4\u9732\u4e8e\u9999\u70df\u70df\u96fe\u7684\u80ba\u7ec4\u7ec7\u66f4\u4e30\u5bcc\u7684\u67d3\u8272\uff08\u5bf9\u7167\u7ec4\uff09\u3002\n<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1b611fe elementor-widget elementor-widget-text-editor\" data-id=\"1b611fe\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>\u81ea\u566c\u53d7\u635f\u5bfc\u81f4\u80ba\u8870\u8001\u7ec6\u80de\u79ef\u805a<\/h3><p>\u00a0<\/p><p>Zhang\u53ca\u5176\u540c\u4e8b\u5148\u524d\u7684\u7814\u7a76\u663e\u793a\uff0c\u81ea\u566c\u53d7\u635f\u4f1a\u5bfc\u81f4\u9999\u70df\u70df\u96fe\u5f15\u8d77\u7684\u80ba\u7ea4\u7ef4\u5316\u3002\u56e0\u6b64\uff0c\u7814\u7a76\u5c0f\u7ec4\u8bd5\u56fe\u5c06\u81ea\u566c\u53d7\u635f\u4e0e\u9999\u70df\u70df\u96fe\u5f15\u8d77\u7684\u7ec6\u80de\u8870\u8001\u8054\u7cfb\u8d77\u6765\uff0c\u56e0\u4e3a\u81ea\u566c\u5728\u8870\u8001\u4e2d\u7684\u4f5c\u7528\u4ecd\u7136\u6a21\u7cca\u3002\u4ed6\u4eec\u53d1\u73b0\uff0c\u4e0e\u81ea\u566c\u76f8\u5173\u7684\u4e00\u79cd\u79f0\u4e3aLC3 II\u7684\u86cb\u767d\u8d28\u5728\u7528\u5377\u70df\u718f\u5236\u63d0\u53d6\u7269\uff08CSE\uff09\u5904\u7406\u540e\uff0c\u5728\u5b9e\u9a8c\u5ba4\u57f9\u517b\u76bf\u4e2d\u57f9\u517b\u7684\u80ba\u7ec6\u80de\u4e2d\u8d77\u521d\u589e\u52a0\uff0c\u4f46\u968f\u540e\u4e0b\u964d\u3002\u6b64\u5916\uff0c\u4ed6\u4eec\u4f7f\u7528\u4e00\u79cd\u79f0\u4e3a\u96f7\u5e15\u9709\u7d20\u7684\u836f\u5242\u6765\u8bf1\u5bfc\u81ea\u566c\uff0c\u4ece\u800c\u963b\u6b62\u4e86CSE\u8bf1\u5bfc\u7684\u80ba\u7ec6\u80de\u8870\u8001\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u5c3d\u7ba1\u81ea\u566c\u662f\u5728CSE\u66b4\u9732\u540e\u6700\u521d\u8bf1\u5bfc\u7684\uff0c\u4f46CSE\u6700\u7ec8\u4f1a\u51cf\u5c11\u81ea\u566c\u4ee5\u8bf1\u5bfc\u8870\u8001\u3002<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9d2012f elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"9d2012f\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"351\" height=\"220\" src=\"https:\/\/cytologics.com\/wp-content\/uploads\/2021\/04\/747762_325427.webp\" class=\"attachment-full size-full wp-image-9264\" alt=\"NMN\u6e1b\u8f15\u9999\u7159\u8a98\u767c\u7684\u80ba\u7e96\u7dad\u5316\u4e2d\u7684\u80ba\u640d\u50b7\" \/><\/figure><div class=\"elementor-image-box-content\"><p class=\"elementor-image-box-description\">(Zhang et al., 2021 | Free Radical Biology and Medicine) \u9999\u70df\u70df\u96fe\u5f15\u8d77\u7684\u8870\u8001\u662f\u7531\u4e8e\u81ea\u566c\u53d7\u635f\u6240\u81f4\u3002\u5de6\u56fe\u663e\u793a\u4e86\u4e09\u5c0f\u65f6\u540eLC3 II\u81ea\u566c\u76f8\u5173\u86cb\u767d\u7684\u6700\u521d\u589e\u52a0\uff0c\u7136\u540e\u4e0e\u672a\u5904\u7406\u7684\u7ec6\u80de\uff08C\uff09\u76f8\u6bd4\uff0c\u5728\u7ecf\u9999\u70df\u70df\u96fe\u63d0\u53d6\u7269\uff08CSE\uff09\u5904\u7406\u7684\u7ec6\u80de\u4e2d\u5176\u4e0b\u964d\u3002\u53f3\u56fe\u663e\u793a\u4e86\u7528CSE\u5904\u7406\u7684\u8870\u8001\u7ec6\u80de\u7684\u767e\u5206\u6bd4\u589e\u52a0\uff0c\u4f46\u662f\u7528\u81ea\u566c\u8bf1\u5bfc\u7684\u96f7\u5e15\u9709\u7d20\u6cbb\u7597\u5982\u4f55\u62ef\u6551\u4e86\u8fd9\u4e9b\u7ec6\u80de\u3002\u7528\u81ea\u566c\u6291\u5236\u52423MA\u5904\u7406\u80ba\u7ec6\u80de\u4e5f\u4fc3\u8fdb\u4e86\u7ec6\u80de\u8870\u8001\u7684\u589e\u52a0\u3002\u8fd9\u4e9b\u7ed3\u679c\u663e\u793a\uff0c\u9999\u70df\u70df\u96fe\u5f15\u8d77\u7684\u8870\u8001\u5f52\u56e0\u4e8e\u81ea\u566c\u7684\u6291\u5236\u3002\n<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-14594e9 elementor-widget elementor-widget-text-editor\" data-id=\"14594e9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>\u6709\u5bb3\u7684\u542b\u6c27\u5206\u5b50\u4fc3\u6210\u7ec6\u80de\u8870\u8001<\/h3><p>\u00a0<\/p><p>\u81ea\u7ebf\u7c92\u4f53\u4e2dROS\u7684\u79ef\u7d2f\u5df2\u6210\u4e3a\u8870\u8001\u548c\u7ec6\u80de\u8870\u8001\u7684\u70ed\u95e8\u8bdd\u9898\u4ee5\u6765\uff0cZhang\u548c\u4ed6\u7684\u540c\u4e8b\u60f3\u77e5\u9053\u7ebf\u7c92\u4f53ROS\u7684\u79ef\u7d2f\u662f\u5426\u662f\u7531\u9999\u70df\u70df\u96fe\u5f15\u8d77\u7684\u81ea\u566c\u53d7\u635f\u5f15\u8d77\u7684\u3002\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u7ecfCSE\u5904\u7406\u7684\u80ba\u7ec6\u80de\u4e2d\u7ebf\u7c92\u4f53ROS\u542b\u91cf\u5347\u9ad8\uff0c\u800cmitoquinone\uff08\u4e00\u79cd\u6e05\u9664ROS\u7684\u5316\u5408\u7269\uff09\u6cbb\u7597\u53ef\u4fdd\u62a4\u7ec6\u80de\u514d\u4e8e\u8870\u8001\u3002\u4ed6\u4eec\u5f97\u51fa\u7ed3\u8bba\uff0c\u81ea\u566c\u53d7\u635f\u4f1a\u5bfc\u81f4\u6709\u5bb3\u7684\u7ebf\u7c92\u4f53ROS\u79ef\u7d2f\uff0c\u4ece\u800c\u5bfc\u81f4\u8870\u8001\u3002<\/p><p>\u00a0<\/p><h3>NMN\u6062\u590d\u81ea\u566c\u4ee5\u51cf\u8f7b\u7ec6\u80de\u8870\u8001<\/h3><p>\u00a0<\/p><p>NMN\u662f\u91cd\u8981\u5206\u5b50\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178\uff08NAD 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data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"566\" height=\"137\" src=\"https:\/\/cytologics.com\/wp-content\/uploads\/2021\/04\/954424_632425.webp\" class=\"attachment-full size-full wp-image-9265\" alt=\"NMN\u6e1b\u8f15\u9999\u7159\u8a98\u767c\u7684\u80ba\u7e96\u7dad\u5316\u4e2d\u7684\u80ba\u640d\u50b7\" \/><\/figure><div class=\"elementor-image-box-content\"><p class=\"elementor-image-box-description\">(Zhang et al., 2021 | Free Radical Biology and Medicine)NMN\u901a\u904e\u523a\u6fc0\u81ea\u566c\u963b\u6b62\u7d30\u80de\u8870\u8001\u3002\u5716\u50cf\u986f\u793a\u4e86\u8207\u8870\u8001\u76f8\u95dc\u7684\u03b2-\u534a\u4e73\u7cd6\u82f7\u9176\u80ba\u7d30\u80de\u67d3\u8272\u3002\u9999\u7159\u7159\u9727\u63d0\u53d6\u7269\u589e\u52a0\u4e86\u85cd\u8272\u03b2-\u534a\u4e73\u7cd6\u82f7\u9176\u7684\u67d3\u8272\uff0c\u986f\u793a\u8870\u8001\u3001\u975e\u589e\u503c\u7684\u7d30\u80de\u5b58\u5728\u3002NMN\u633d\u6551\u4e86\u9019\u7a2e\u6548\u61c9\uff0c\u4e26\u6e1b\u5c11\u4e86\u8870\u8001\u7684\u975e\u589e\u6b96\u7d30\u80de\u7684\u7a4d\u7d2f\uff0c\u4f46Sitruin\u6291\u88fd\u5291Ex527\u9006\u8f49\u4e86NMN\u7684\u6548\u61c9\u3002\u53f3\u5716\u4ee3\u8868\u8a72\u5716\u50cf\u7684\u767c\u73fe\uff0c\u8868\u660eNMN\u53ef\u4ee5\u4fdd\u7559\u7d30\u80de\uff0c\u4f46Ex527\u6c89\u9ed8\u8abf\u7bc0\u86cb\u767d\u7684\u6291\u88fd\u5291\u6703\u589e\u52a0\u8870\u8001\u7684\u975e\u589e\u6b96\u7d30\u80de\u5806\u7a4d\u3002\u9019\u4e9b\u7d50\u679c\u8868\u660e\uff0cNMN\u901a\u904e\u589e\u52a0Siruin\u86cb\u767d\uff08\u5373SIRT1\uff09\u7684\u529f\u80fd\u4f86\u6062\u5fa9\u81ea\u566c\uff0c\u5f9e\u800c\u6e1b\u5c11\u8870\u8001\u3001\u975e\u589e\u6b96\u7684\u7d30\u80de\u5806\u7a4d\u3002\n<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-77ad272 elementor-widget elementor-widget-text-editor\" data-id=\"77ad272\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>NMN\u7684\u6548\u679c\u4f1a\u8f6c\u6362\u5230\u4eba\u7c7b\u75be\u75c5\u4e0a\u5417\uff1f<\/h3><p>\u00a0<\/p><p>\u201c\u6211\u4eec\u8bc1\u5b9e\u9999\u70df\u70df\u96fe\u6291\u5236\u4e86SIRT1\u7684\u6d3b\u6027\uff0c\u201d Zhang\u53ca\u5176\u540c\u4e8b\u5728\u5176\u8bba\u6587\u4e2d\u8868\u793a\u3002\u4ed6\u4eec\u5728\u63d0\u5230\u4f7f\u7528Sirtuin1\u6fc0\u6d3b\u5242\u6216NMN\u9884\u9632\u80ba\u7ec6\u80de\u8870\u8001\u65f6\u8bf4\uff1a\u201c\u6b64\u5916\uff0c\u6211\u4eec\u8bc1\u660e\u4e86SIRT1\u6fc0\u6d3b\u5242\u548cNAD +\u53ca\u5176\u524d\u4f53\u7684\u8865\u5145\u53ef\u4ee5\u6062\u590dSIRT1\u6d3b\u6027\u5e76\u9632\u6b62(\u80ba\u7ec6\u80de)\u8870\u8001\u3002<\/p><p>\u00a0<\/p><p>\u201d Zhang\u53ca\u5176\u540c\u4e8b\u8fdb\u884c\u7684\u8fd9\u9879\u7814\u7a76\u63ed\u793a\u4e86\u5438\u70df\u5982\u4f55\u5bfc\u81f4\u8bf8\u5982IPF\u4e4b\u7c7b\u7684\u80ba\u90e8\u75be\u75c5\u7684\u53d1\u4f5c\u3002 \u7814\u7a76\u4eba\u5458\u4ecd\u5c06\u9700\u8981\u8fdb\u884c\u672a\u6765\u7684\u4eba\u7c7b\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ee5\u786e\u5b9aNMN\u9884\u9632\u8870\u8001\u7ec6\u80de\u5806\u79ef\u548cIPF\u7684\u76ca\u5904\u662f\u5426\u9002\u7528\u4e8e\u5438\u70df\u8005\u3002<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-da37396 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"da37396\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img loading=\"lazy\" decoding=\"async\" width=\"624\" height=\"255\" src=\"https:\/\/cytologics.com\/wp-content\/uploads\/2021\/04\/938153_4592091.webp\" class=\"attachment-full size-full wp-image-9266\" alt=\"NMN\u6e1b\u8f15\u9999\u7159\u8a98\u767c\u7684\u80ba\u7e96\u7dad\u5316\u4e2d\u7684\u80ba\u640d\u50b7\" \/><\/figure><div class=\"elementor-image-box-content\"><p class=\"elementor-image-box-description\">(Zhang et al., 2021 | Free Radical Biology and Medicine)NMN\u6062\u590d\u53d7\u635f\u7684\u7ec6\u80de\u6e05\u9664\u8fc7\u7a0b-\u81ea\u566c-\u9632\u6b62\u9999\u70df\u63a5\u89e6\u540e\u8001\u5316\uff0c\u975e\u589e\u6b96\u7684\u7ec6\u80de\u79ef\u805a\u548c\u80ba\u7ea4\u7ef4\u5316\u3002 NMN\u4f1a\u63d0\u9ad8NAD +\u6c34\u5e73\u4ee5\u4fc3\u8fdbSirtuin1\uff08SIRT1\uff09\u529f\u80fd\u3002 SIRT1\u4ece\u523a\u6fc0\u81ea\u566c\u7684\u86cb\u767d\u8d28LC3\u4e2d\u53bb\u9664\u4e86\u79f0\u4e3a\u4e59\u9170\u57fa\u7684\u5206\u5b50\u6807\u7b7e\u3002\u81ea\u566c\u6709\u52a9\u4e8e\u4ece\u7ec6\u80de\u7684\u53d1\u7535\u7ed3\u6784\u7ebf\u7c92\u4f53\u4e2d\u6e05\u9664\u6709\u5bb3\u7684\u542b\u6c27\u5206\u5b50\uff0c\u79f0\u4e3a\u6d3b\u6027\u6c27\uff0c\u4ece\u800c\u6291\u5236\u8870\u8001\uff0c\u975e\u589e\u6b96\u7684\u7ec6\u80de\u5806\u79ef\u548c\u80ba\u7ea4\u7ef4\u5316\u3002\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\uff0cNAD +\u6c34\u5e73\u4e0b\u964d\uff0c\u5bfc\u81f4\u8be5\u8fc7\u7a0b\u53d7\u635f\uff0c\u7ee7\u800c\u5f15\u8d77DNA\u635f\u4f24\uff0c\u4ece\u800c\u6fc0\u6d3bDNA\u4fee\u590d\u86cb\u767dPARPs\uff0c\u4ece\u800c\u8fdb\u4e00\u6b65\u6d88\u8017NAD +\uff0c\u4ece\u800c\u5f62\u6210\u6076\u6027\u5faa\u73af\uff0c\u5bfc\u81f4\u80ba\u7ea4\u7ef4\u5316\u3002\n<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b3b888a elementor-widget elementor-widget-text-editor\" data-id=\"b3b888a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u53c2\u8003\u6587\u732e:<\/p><p>\u00a0<\/p><p>Zhang Y, Huang W, Zheng Z, Wang W, Yuan Y, Hong Q, Lin J, Li X, Meng Y. Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis. Free Radic Biol Med. 2021 Feb 17:S0891-5849(21)00093-9. doi: 10.1016\/j.freeradbiomed.2021.02.013. Epub ahead of print. PMID: 33609723<\/p><p>\u00a0<\/p><p>\u6587\u7ae0\u6765\u6e90:<\/p><p>\u00a0<\/p><p>https:\/\/www.nmn.com\/news\/nmn-alleviates-lung-damage-cigarette-induced-pulmonary-fibrosis<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>\u7159\u9170\u80fa\u55ae\u6838\u82f7\u9178\uff08NMN\uff09\u6e05\u9664\u9999\u7159\u7159\u9727\u4e2d\u8001\u5316\u7684\u975e\u589e\u6b96\u80ba\u7d30\u80de\u3002 By Brett J. Weiss Publish&#8230;<\/p>","protected":false},"author":1,"featured_media":9260,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[180],"tags":[],"class_list":["post-9259","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-180","nt-post-class","","excerpt-none"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-08-02 15:41:55","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"rttpg_featured_image_url":{"full":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/15620_896109.jpg",1115,670,false],"landscape":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/15620_896109.jpg",1115,670,false],"portraits":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/15620_896109.jpg",1115,670,false],"thumbnail":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/15620_896109-150x150.jpg",150,150,true],"medium":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/15620_896109-300x180.jpg",300,180,true],"large":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/15620_896109-1024x615.jpg",960,577,true],"1536x1536":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/15620_896109.jpg",1115,670,false],"2048x2048":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/15620_896109.jpg",1115,670,false],"trp-custom-language-flag":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/15620_896109-18x12.jpg",18,12,true],"goldsmith-quickview":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/15620_896109.jpg",60,36,false],"goldsmith-panel":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/15620_896109.jpg",80,48,false],"goldsmith-mini":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/15620_896109.jpg",300,180,false],"goldsmith-medium":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/15620_896109.jpg",370,222,false],"goldsmith-square":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/15620_896109.jpg",500,300,false],"goldsmith-grid":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/15620_896109.jpg",767,461,false]},"rttpg_author":{"display_name":"nkcomys","author_link":"https:\/\/cytologics.com\/sc\/author\/nkcomys\/"},"rttpg_comment":0,"rttpg_category":"<a href=\"https:\/\/cytologics.com\/sc\/%e7%a7%91%e7%a0%94%e8%b3%87%e8%a8%8a\/\" rel=\"category tag\">\u79d1\u7814\u8cc7\u8a0a<\/a>","rttpg_excerpt":"\u7159\u9170\u80fa\u55ae\u6838\u82f7\u9178\uff08NMN\uff09\u6e05\u9664\u9999\u7159\u7159\u9727\u4e2d\u8001\u5316\u7684\u975e\u589e\u6b96\u80ba\u7d30\u80de\u3002 By Brett J. 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