{"id":9354,"date":"2020-10-01T23:32:14","date_gmt":"2020-10-01T15:32:14","guid":{"rendered":"https:\/\/www.cytologics.com.hk\/?p=9354"},"modified":"2024-03-15T16:17:09","modified_gmt":"2024-03-15T08:17:09","slug":"%e5%8f%b2%e4%b8%8a%e6%9c%80%e5%ae%8c%e6%95%b4nad%e5%85%a8%e4%bb%8b%e7%b4%b9","status":"publish","type":"post","link":"https:\/\/cytologics.com\/sc\/%e5%8f%b2%e4%b8%8a%e6%9c%80%e5%ae%8c%e6%95%b4nad%e5%85%a8%e4%bb%8b%e7%b4%b9\/","title":{"rendered":"\u53f2\u4e0a\u6700\u5b8c\u6574NAD+\u5168\u4ecb\u7ecd"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"9354\" class=\"elementor elementor-9354\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"gap-default elementor-section elementor-top-section elementor-element elementor-element-27c3e5a6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"27c3e5a6\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container 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+\u751f\u7269\u5408\u6210\u7684\u8865\u6551\u9014\u5f84\u4f7f\u7528\u5929\u7136\u5b58\u5728\u7684\u7ef4\u751f\u7d20\u3002\u8fd9\u4e9b\u7ef4\u751f\u7d20\u5305\u62ec\u70df\u9170\u80fa(NAM)\u3001\u70df\u9178(NA)\u3001\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178\uff08NMN\uff09\u548c\u70df\u9170\u80fa\u6838\u7cd6\u82f7\uff08NR\uff09\uff0c\u70df\u9178\u901a\u8fc7\u4e09\u4e2a\u6b65\u9aa4\u8f6c\u5316\u4e3aNAD +\u3002\u7b2c\u4e00\u6b65\uff0cNAPRT\u9176\u5c06\u70df\u9178\u8f6c\u5316\u4e3a\u70df\u9178\u5355\u6838\u82f7\u9178\uff08NAMN\uff09\u3002\u5728\u7b2c\u4e8c\u6b65\u4e2d\uff0c\u9176NMNAT\u5c06NAMN\u8f6c\u6362\u4e3a\u70df\u9178\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178\uff08NAAD\uff09\u3002\u7136\u540e\uff0cNAD +\u5408\u6210\u9176\uff08NADS\uff09\u9176\u5c06NAAD\u8f6c\u5316\u4e3aNAD +\u3002<\/p><p>\u00a0<\/p><p>\u8865\u6551\u9014\u5f84\u4e2d\u7684NAD +\u751f\u7269\u5408\u6210\u6d89\u53ca\u70df\u9170\u80fa\u901a\u8fc7\u78f7\u9178\u6838\u7cd6\u57fa\u8f6c\u79fb\u9176NMNAT\u8f6c\u5316\u4e3aNMN\u3002\u8fd9\u79cd\u9176\u5c06NMN\u8f6c\u5316\u4e3aNAD +\u3002<\/p><p>\u00a0<\/p><p>NR\u5728\u9176NRK\u7684\u4f5c\u7528\u4e0b\u8f6c\u5316\u4e3aNMN\u3002 NMN\u901a\u8fc7NMNAT\u7684\u9176\u4fc3\u6d3b\u6027\u8f6c\u5316\u4e3aNAD +\u3002<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4c181cd elementor-widget elementor-widget-image\" data-id=\"4c181cd\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"632\" src=\"https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/444511_136078.jpg\" class=\"attachment-full size-full wp-image-9335\" alt=\"NMN VS NR\uff1a\u9019\u5169\u7a2e NAD+ \u524d\u9ad4\u4e4b\u9593\u7684\u5dee\u7570\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-715b6a5 elementor-widget elementor-widget-text-editor\" data-id=\"715b6a5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>\u5b83\u662f\u4ec0\u4e48\u505a\u7684\uff1f<\/h3><p>\u00a0<\/p><p>NAD +\u7531\u901a\u8fc7\u78f7\u9178\u57fa\u56e2\u8fde\u63a5\u7684\u4e24\u4e2a\u6838\u82f7\u9178\u7ec4\u6210\u3002\u4e00\u4e2a\u6838\u82f7\u9178\u5305\u542b\u817a\u560c\u5464\u6838\u82f7\u78b1\u57fa\uff0c\u53e6\u4e00\u4e2a\u6838\u82f7\u9178\u5305\u542b\u70df\u9170\u80fa\u3002<\/p><p>\u00a0<\/p><h3>NAD+\u751f\u7269\u5408\u6210\u7684\u524d\u4f53<\/h3>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a4cfe8e elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"a4cfe8e\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img loading=\"lazy\" decoding=\"async\" width=\"680\" height=\"128\" src=\"https:\/\/cytologics.com\/wp-content\/uploads\/2020\/10\/575905_445397.jpg\" class=\"attachment-full size-full wp-image-9359\" alt=\"\u53f2\u4e0a\u6700\u5b8c\u6574NAD+\u5168\u4ecb\u7d39\" \/><\/figure><div class=\"elementor-image-box-content\"><p class=\"elementor-image-box-description\">Braidy et al. (2019). Chemical structures of NAD+ precursors\n<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8590598 elementor-widget elementor-widget-text-editor\" data-id=\"8590598\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>NAD +\u524d\u4f53\u8865\u5145\u5242\u4ee3\u8868\u4e86\u4e00\u79cd\u6f5c\u5728\u7684\u6cbb\u7597\u7b56\u7565\uff0c\u53ef\u4ee5\u51cf\u7f13\u8870\u8001\u5e76\u6539\u5584\u4e0e\u5e74\u9f84\u6709\u5173\u7684\u75be\u75c5\u3002\u76ee\u524d\u5c1a\u672a\u8bc1\u660e\u53e3\u670dNAD +\u53ef\u4ee5\u589e\u52a0\u4f53\u5185NAD +\u7684\u6c34\u5e73\u3002\u4f46\u662f\uff0c\u8865\u5145\u524d\u4f53\uff08\u4f8b\u5982NMN\u6216NR\uff09\u53ef\u80fd\u4f1a\u63d0\u4f9b\u8fd9\u4e9b\u76ca\u5904\u3002<\/p><p>\u00a0<\/p><p>\u7814\u7a76\u663e\u793a\uff0c\u8865\u5145NMN\u53ef\u4ee5\u9884\u9632\u5404\u79cd\u75be\u75c5\u3002\u8fd9\u79cd\u6548\u5e94\u53ef\u80fd\u662f\u901a\u8fc7\u63d0\u5347\u4f53\u5185NAD+\u6c34\u5e73\u800c\u4ea7\u751f\u7684\u3002\u8865\u5145NMN\u53ef\u4ee5\u51cf\u5c11\u80a5\u80d6\u3001\u4fdd\u62a4\u8840\u7ba1\u514d\u53d7\u635f\u4f24\u3002\u8fd9\u4e9b\u76ca\u5904\u6765\u81ea\u4e8e\u963f\u8328\u6d77\u9ed8\u75c7\u3001\u8ba4\u77e5\u969c\u788d\u548c\u795e\u7ecf\u708e\u75c7\u7684\u5c0f\u9f20\u75be\u75c5\u6a21\u578b\u3002\u8865\u5145NR\u5bf9\u5c0f\u9f20\u4e5f\u6709\u7c7b\u4f3c\u7684\u6709\u76ca\u6548\u679c\u3002<\/p><p>\u00a0<\/p><p>\u8fd9\u4e9b\u5bf9\u5c0f\u9f20\u7684\u6709\u76ca\u5f71\u54cd\u80fd\u5e94\u7528\u4e8e\u4eba\u7c7b\u5417\uff1f\u53ea\u6709\u5728\u4eba\u4f53\u4e2d\u8fdb\u884c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u624d\u80fd\u8bc1\u660e\u8fd9\u4e00\u70b9\u3002<\/p><p>\u00a0<\/p><p>\u5728\u8870\u8001\uff0cNMN\u6216NR\u671f\u95f4\uff0c\u54ea\u79cd\u524d\u4f53\u8865\u5145\u5242\u53ef\u4fc3\u8fdb\u4f53\u5185\u66f4\u9ad8\u6c34\u5e73\u7684NAD +\uff1f\u79d1\u5b66\u5bb6\u4e4b\u95f4\u7684\u8fa9\u8bba\u4ecd\u5728\u7ee7\u7eed\u3002<\/p><p>\u00a0<\/p><h3>NAD+\u662f\u8f85\u9176\u8fd8\u662f\u8f85\u56e0\u5b50\uff1f<\/h3><p>\u00a0<\/p><p>NAD +\u662f\u8f85\u56e0\u5b50\u548c\u8f85\u9176\u3002\u8f85\u56e0\u5b50\u662f\u9176\u52a0\u901f\u53cd\u5e94\u6240\u9700\u7684\u975e\u86cb\u767d\u8d28\u5316\u5408\u7269\u3002\u8f85\u52a9\u56e0\u5b50\u662f\u201c\u8f85\u52a9\u5206\u5b50\u201d\uff0c\u6709\u52a9\u4e8e\u751f\u5316\u8f6c\u5316\u3002<\/p><p>\u00a0<\/p><p>NAD +\u5728\u65b0\u9648\u4ee3\u8c22\u7684\u7535\u5b50\u8f6c\u79fb\u53cd\u5e94\u4e2d\u8d77\u8f85\u52a9\u56e0\u5b50\u7684\u4f5c\u7528\u3002\u4f46\u662f\uff0cNAD +\u5728\u4e0e\u79f0\u4e3aSirtuins\u7684\u86cb\u767d\u8d28\u7ed3\u5408\u65f6\u5145\u5f53\u8f85\u9176\u3002\u8be5\u5206\u5b50\u4e0e\u8fd9\u4e9b\u86cb\u767d\u8d28\u7ed3\u5408\uff0c\u968f\u540e\u91ca\u653e\u5b83\u4eec\u4ee5\u4f9b\u8fdb\u4e00\u6b65\u4f7f\u7528\u3002<\/p><p>\u00a0<\/p><h3>NAD+\u7684\u6c34\u5e73\u964d\u4f4e\u4f1a\u53d1\u751f\u4ec0\u4e48\u4e8b\uff1f<\/h3><p>\u00a0<\/p><p>\u5927\u91cf\u7814\u7a76\u663e\u793a\uff0c\u5728\u8425\u517b\u5931\u8c03\u7684\u60c5\u51b5\u4e0b\uff08\u4f8b\u5982\u80a5\u80d6\u75c7\u548c\u8870\u8001\uff09\uff0cNAD +\u7684\u6c34\u5e73\u4f1a\u964d\u4f4e\u3002 NAD +\u7684\u6c34\u5e73\u964d\u4f4e\u4f1a\u5bfc\u81f4\u65b0\u9648\u4ee3\u8c22\u95ee\u9898\u3002\u8fd9\u4e9b\u95ee\u9898\u53ef\u80fd\u5bfc\u81f4\u75be\u75c5\uff0c\u5305\u62ec\u80a5\u80d6\u548c\u80f0\u5c9b\u7d20\u62b5\u6297\u3002\u80a5\u80d6\u4f1a\u5bfc\u81f4\u7cd6\u5c3f\u75c5\u548c\u9ad8\u8840\u538b\u3002<\/p><p>\u00a0<\/p><p>\u4f4eNAD+\u6c34\u5e73\u4f1a\u5f15\u53d1\u4ee3\u8c22\u7d0a\u4e71\uff0c\u9ad8\u8840\u538b\u548c\u5176\u4ed6\u5fc3\u810f\u529f\u80fd\u4e0b\u964d\u4f1a\u5411\u5927\u8111\u53d1\u9001\u7834\u574f\u6027\u7684\u538b\u529b\u6ce2\uff0c\u4ece\u800c\u5bfc\u81f4\u8ba4\u77e5\u969c\u788d\u3002<\/p><p>\u00a0<\/p><p>\u4ee5NAD+\u4ee3\u8c22\u4e3a\u9776\u70b9\u662f\u9884\u9632\u4ee3\u8c22\u6027\u75be\u75c5\u548c\u5176\u4ed6\u5e74\u9f84\u76f8\u5173\u75be\u75c5\u7684\u5b9e\u7528\u8425\u517b\u4ecb\u5165\u63aa\u65bd\u3002\u6709\u597d\u4e9b\u7814\u7a76\u663e\u793a\uff0c\u8865\u5145NAD+\u8865\u5145\u5242\u53ef\u4ee5\u6539\u5584\u80a5\u80d6\u5f15\u8d77\u7684\u80f0\u5c9b\u7d20\u62b5\u6297\u3002\u5728\u5e74\u9f84\u76f8\u5173\u75be\u75c5\u7684\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u8865\u5145NAD+\u8865\u5145\u5242\u53ef\u6539\u5584\u75be\u75c5\u75c7\u72b6\u3002\u8fd9\u663e\u793a\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\uff0cNAD+\u7684\u6c34\u5e73\u964d\u4f4e\u53ef\u80fd\u5bfc\u81f4\u5e74\u9f84\u76f8\u5173\u75be\u75c5\u7684\u53d1\u751f\u3002<\/p><p>\u00a0<\/p><p>\u9884\u9632NAD +\u7684\u4e0b\u964d\u4e3a\u5bf9\u6297\u65b0\u9648\u4ee3\u8c22\u7d0a\u4e71\u63d0\u4f9b\u4e86\u4e00\u79cd\u6709\u5e0c\u671b\u7684\u7b56\u7565\u3002\u7531\u4e8eNAD +\u7684\u6c34\u5e73\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u800c\u964d\u4f4e\uff0c\u8fd9\u53ef\u80fd\u5bfc\u81f4DNA\u4fee\u590d\u3001\u7ec6\u80de\u5e94\u6fc0\u53cd\u5e94\u548c\u80fd\u91cf\u4ee3\u8c22\u8c03\u8282\u964d\u4f4e\u3002<\/p><p>\u00a0<\/p><h3>\u6f5c\u5728\u7684\u76ca\u5904<\/h3><p>\u00a0<\/p><p>NAD +\u5bf9\u4e8e\u751f\u7269\u7684\u7c92\u7ebf\u4f53\u7ef4\u6301\u548c\u6709\u5173\u8870\u8001\u7684\u57fa\u56e0\u8c03\u63a7\u975e\u5e38\u91cd\u8981\u3002\u4f46\u662f\uff0c\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\uff0c\u6211\u4eec\u4f53\u5185\u7684NAD +\u542b\u91cf\u4f1a\u6025\u5267\u4e0b\u964d\u3002 \u201c\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\uff0c\u6211\u4eec\u4f1a\u5931\u53bbNAD +\u3002 \u523050\u5c81\u65f6\uff0c\u60a8\u7684\u6c34\u5e73\u5df2\u7ecf\u662f20\u5c81\u65f6\u7684\u4e00\u534a\u5de6\u53f3\u3002\u201d\u54c8\u4f5b\u5927\u5b66\u7684\u5927\u536b\u00b7\u8f9b\u514b\u83b1\u5c14\u6559\u6388\uff08Prof. David Sinclair\uff09\u5728\u63a5\u53d7\u91c7\u8bbf\u65f6\u8bf4\u3002<\/p><p>\u00a0<\/p><p>\u7814\u7a76\u663e\u793a\uff0cNAD+\u7684\u51cf\u5c11\u4e0e\u4e0e\u5e74\u9f84\u6709\u5173\u7684\u75be\u75c5\u6709\u5173\uff0c\u5305\u62ec\u52a0\u901f\u8870\u8001\u3001\u4ee3\u8c22\u7d0a\u4e71\u3001\u5fc3\u810f\u75c5\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u3002 NAD+ \u6c34\u5e73\u7684\u964d\u4f4e\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u75be\u75c5\u6709\u5173\uff0c\u8fd9\u662f\u7531\u4e8e\u529f\u80fd\u6027\u65b0\u9648\u4ee3\u8c22\u8f83\u5c11\u6240\u81f4\u3002\u4f46\u662f\u8865\u5145NAD 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Sirtuins\u53ef\u4ee5\u7ef4\u6301\u57fa\u56e0\u7ec4\u5b8c\u6574\u6027\uff0c\u4fc3\u8fdbDNA\u4fee\u590d\uff0c\u5e76\u5728\u6a21\u578b\u52a8\u7269\u4e2d\u663e\u793a\u51fa\u4e0e\u8870\u8001\u76f8\u5173\u7684\u7279\u6027\uff0c\u4f8b\u5982\u5ef6\u957f\u5bff\u547d\u3002<\/p><p>\u00a0<\/p><p>NAD +\u662f\u9a71\u52a8\u57fa\u56e0\u53d1\u6325\u4f5c\u7528\u7684\u71c3\u6599\u3002\u4f46\u662f\u5c31\u50cf\u6c7d\u8f66\u4e0d\u80fd\u6ca1\u6709\u71c3\u6599\u5c31\u65e0\u6cd5\u9a7e\u9a76\u4e00\u6837\uff0cSirtuins\u9700\u8981NAD +\u624d\u80fd\u8fd0\u4f5c\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u63d0\u9ad8\u4f53\u5185NAD\u7684 +\u6c34\u5e73\u53ef\u6fc0\u6d3b\u6c89\u9ed8\u8c03\u8282\u86cb\u767d\uff0c\u5e76\u5ef6\u957f\u9175\u6bcd\u3001\u8815\u866b\u548c\u5c0f\u9f20\u7684\u5bff\u547d\u3002\u5c3d\u7ba1\u8865\u5145NAD 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class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img loading=\"lazy\" decoding=\"async\" width=\"235\" height=\"160\" src=\"https:\/\/cytologics.com\/wp-content\/uploads\/2020\/10\/719942_389597.jpg\" class=\"attachment-full size-full wp-image-9360\" alt=\"\u53f2\u4e0a\u6700\u5b8c\u6574NAD+\u5168\u4ecb\u7d39\" \/><\/figure><div class=\"elementor-image-box-content\"><p class=\"elementor-image-box-description\">Zhang et al. (2016)\n<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-14594e9 elementor-widget elementor-widget-text-editor\" data-id=\"14594e9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u5bf9\u8001\u9f20\u6765\u8bf4\uff0c\u201c\u9752\u5e74\u4e4b\u6cc9\u201d\u7684\u641c\u5bfb\u53ef\u80fd\u5df2\u7ecf\u7ed3\u675f\u3002\u4f46\u662f\uff0c\u5bf9\u4e8e\u4eba\u7c7b\u6765\u8bf4\uff0c\u79d1\u5b66\u5bb6\u4eec\u8ba4\u4e3a\u6211\u4eec\u8fd8\u6ca1\u627e\u5230\u3002 NMN\u548cNR\u5728\u4eba\u4f53\u4e2d\u7684\u4e34\u5e8a\u8bd5\u9a8c\u53ef\u80fd\u4f1a\u5728\u672a\u6765\u51e0\u5e74\u5185\u63d0\u4f9b\u7ed3\u679c\u3002<\/p><p>\u00a0<\/p><h3>\u6211\u4eec\u5982\u4f55\u63d0\u9ad8\u4f53\u5185NAD+\u7684\u542b\u91cf<\/h3><p>\u00a0<\/p><p>\u53ef\u4ee5\u901a\u8fc7\u4fc3\u8fdbNAD +\u7684\u5408\u6210\u6765\u63d0\u9ad8NAD +\u7684\u6c34\u5e73\uff0c\u5373\u589e\u5f3aNAD 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