{"id":8443,"date":"2022-02-24T22:27:00","date_gmt":"2022-02-24T14:27:00","guid":{"rendered":"https:\/\/www.cytologics.com.hk\/?p=8443"},"modified":"2024-05-18T16:29:59","modified_gmt":"2024-05-18T08:29:59","slug":"%e7%a0%94%e7%a9%b6%e8%a1%a8%e6%98%8e-nmn%e5%8f%af%e8%83%bd%e5%b0%8d%e7%bd%95%e8%a6%8b%e7%9a%84%e5%82%b3%e6%9f%93%e6%80%a7%e7%a5%9e%e7%b6%93%e9%80%80%e8%a1%8c%e6%80%a7%e7%96%be%e7%97%85%e6%9c%89","status":"publish","type":"post","link":"https:\/\/cytologics.com\/tc\/%e7%a0%94%e7%a9%b6%e8%a1%a8%e6%98%8e-nmn%e5%8f%af%e8%83%bd%e5%b0%8d%e7%bd%95%e8%a6%8b%e7%9a%84%e5%82%b3%e6%9f%93%e6%80%a7%e7%a5%9e%e7%b6%93%e9%80%80%e8%a1%8c%e6%80%a7%e7%96%be%e7%97%85%e6%9c%89\/","title":{"rendered":"NMN\u53ef\u80fd\u5c0d\u7f55\u898b\u7684\u50b3\u67d3\u6027\u795e\u7d93\u9000\u884c\u6027\u75be\u75c5\u6709\u5e6b\u52a9"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"8443\" class=\"elementor elementor-8443\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"gap-default elementor-section elementor-top-section elementor-element elementor-element-27c3e5a6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"27c3e5a6\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-393f0668\" data-id=\"393f0668\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6935219 elementor-widget elementor-widget-text-editor\" data-id=\"6935219\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h1>\u7528\u7159\u9170\u80fa\u55ae\u6838\u82f7\u9178 (NMN) \u63d0\u9ad8 NAD+ \u6c34\u5e73\u53ef\u6539\u5584\u7531\u670a\u75c5\u6bd2\u75be\u75c5\u5f15\u8d77\u7684\u53d7\u640d\u7c92\u7dda\u9ad4\u7684\u6e05\u9664\u7f3a\u9677\uff0c\u5f9e\u800c\u4fdd\u8b77\u9019\u4e9b\u795e\u7d93\u5143\u514d\u65bc\u7d30\u80de\u6b7b\u4ea1\u3002<\/h1>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-705d2d0e elementor-widget elementor-widget-text-editor\" data-id=\"705d2d0e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>By Jonathan D. Grinstein, Ph.D.<\/p><p>Published: 2:29 p.m. PST Feb 24, 2022 | Updated: 10:49 am PST Mar 2, 2022<\/p><h3>\u00a0<\/h3><h3><strong>\u91cd\u5927\u4eae\u9ede<\/strong><\/h3><div><strong>\u00a0<\/strong><\/div><ul><li>\u5728\u4e00\u7a2e\u88ab\u7a31\u70ba\u670a\u75c5\u6bd2\u75c5\u7684\u7f55\u898b\u795e\u7d93\u9000\u884c\u6027\u75be\u75c5\u7684\u5c0f\u9f20\u7d30\u80de\u6a21\u578b\u4e2d\uff0c\u7c92\u7dda\u9ad4\u81ea\u566c&#8211;\u6e05\u9664\u53d7\u640d\u7684\u7c92\u7dda\u9ad4&#8211;\u7684\u529f\u80fd\u53d7\u640d\u3002<\/li><li>\u5728\u60a3\u6709\u670a\u75c5\u6bd2\u75c5\u7684\u795e\u7d93\u7d30\u80de\u4e2d\u88dc\u5145NMN\u6216\u5c3f\u77f3\u7d20A\uff08UA\uff09\u53ef\u660e\u986f\u6062\u5fa9\u7c92\u7dda\u9ad4\u541e\u566c\u4f5c\u7528\u3002<\/li><\/ul><div><ul><li>\u7136\u800c\uff0c\u53ea\u6709NMN\u800c\u4e0d\u662fUA\u80fd\u7de9\u89e3\u670a\u75c5\u6bd2\u5f15\u8d77\u7684\u7c92\u7dda\u9ad4\u640d\u50b7\u548c\u529f\u80fd\u969c\u7919\u4ee5\u53ca\u795e\u7d93\u5143\u7d30\u80de\u6b7b\u4ea1\u3002<\/li><\/ul><p>\u00a0<\/p><\/div><p>\u7531\u65bc 2003 \u5e74\u82f1\u570b\u7206\u767c\u201c\u760b\u725b\u75c5\u201d\u800c\u5f15\u8d77\u516c\u773e\u95dc\u6ce8\u7684\u670a\u75c5\u6bd2\u75c5\u662f\u4e00\u7d44\u53ef\u4ee5\u611f\u67d3\u4eba\u985e\u548c\u52d5\u7269\u7684\u6162\u6027\u3001\u81f4\u547d\u7684\u795e\u7d93\u9000\u884c\u6027\u75be\u75c5\u3002 \u8207\u8a31\u591a\u5176\u4ed6\u795e\u7d93\u9000\u884c\u6027\u75be\u75c5\u4e00\u6a23\uff0c\u5c24\u5176\u662f\u90a3\u4e9b\u8207\u5e74\u9f61\u76f8\u95dc\u7684\u75be\u75c5\uff0c\u670a\u75c5\u6bd2\u75be\u75c5\u2014\u2014\u6216\u50b3\u67d3\u6027\u6d77\u7dbf\u72c0\u8166\u75c5 (TSEs)\u2014\u2014\u6d89\u53ca\u932f\u8aa4\u6298\u758a\u7684\u86cb\u767d\u8cea\uff0c\u5982\u963f\u723e\u8328\u6d77\u9ed8\u75c5\u548c\u5e15\u91d1\u68ee\u75c5\uff0c\u901a\u5e38\u53d7\u5230\u795e\u7d93\u5143\u9ad4\u6301\u7e8c\u7a4d\u7d2f\u7684\u5f71\u97ff\u3002<\/p><p>\u4f86\u81ea\u4e2d\u570b\u5317\u4eac\u7684\u4e2d\u570b\u8fb2\u696d\u5927\u5b78\u7684\u7814\u7a76\u4eba\u54e1Li\u53ca\u5176\u540c\u4e8b\u8868\u660e\uff0c\u5169\u7a2e\u4fc3\u9032NAD+\u7684\u5316\u5408\u7269\u53ef\u4ee5\u4fdd\u8b77\u670a\u75c5\u6bd2\u75c5\u7684\u795e\u7d93\u5143\u514d\u65bc\u6b7b\u4ea1\u3002\u767c\u8868\u5728\u5b78\u8853\u671f\u520a\u300a\u7d30\u80de\u6b7b\u4ea1\u8207\u75be\u75c5\u300b(Cell Death &amp; Disease)\u4e0a\u7684\u7814\u7a76\u986f\u793a\uff0cNMN\u548c\u5c3f\u7d20A\u901a\u904e\u8a98\u5c0e\u6709\u7d72\u5206\u88c2&#8211;\u6e05\u9664\u53d7\u640d\u7c92\u7dda\u9ad4\u7684\u904e\u7a0b\uff0c\u6539\u5584\u4e86\u670a\u75c5\u6bd2\u75c5\u795e\u7d93\u5143\u7684\u5065\u5eb7\u7c92\u7dda\u9ad4\u5eab\u3002\u9019\u4e9b\u767c\u73fe\u8868\u660e\uff0c\u50cf\u9019\u4e9b\u4fc3\u9032NAD+\u7684\u523a\u6fc0\u6709\u7d72\u5206\u88c2\u7684\u5316\u5408\u7269\u53ef\u4ee5\u6210\u70ba\u6cbb\u7642\u670a\u75c5\u6bd2\u75be\u75c5\u7684\u4ecb\u5165\u63aa\u65bd\u3002<\/p><h3><strong>\u53d7\u640d\u7684\u7c92\u7dda\u9ad4\u53ef\u80fd\u4f7f\u670a\u75c5\u6bd2\u75c5\u6301\u7e8c\u5b58\u5728<\/strong><\/h3><div><strong>\u00a0<\/strong><\/div><p>\u201c\u670a\u75c5\u6bd2\u201d\u9019\u500b\u540d\u7a31\u662f\u6307\u7570\u5e38\u7684\u3001\u81f4\u75c5\u7684\u56e0\u5b50\uff0c\u5b83\u5011\u662f\u53ef\u50b3\u64ad\u7684\uff0c\u4e26\u4e14\u6703\u5c0e\u81f4\u7279\u5b9a\u7684\u6b63\u5e38\u7d30\u80de\u86cb\u767d\uff08\u7a31\u70ba\u670a\u75c5\u6bd2\u86cb\u767d\uff09\u7684\u4e0d\u6b63\u78ba\u6298\u758a\uff0c\u9019\u7a2e\u86cb\u767d\u5728\u5927\u8166\u4e2d\u5f88\u666e\u904d\u3002 \u670a\u75c5\u6bd2\u75be\u75c5\uff0c\u5982\u514b\u96c5\u6c0f\u75c5\uff0c\u53ef\u80fd\u81ea\u767c\u767c\u751f\u3001\u907a\u50b3\u6216\u901a\u904e\u63a5\u89f8\u53d7\u611f\u67d3\u7684\u7d44\u7e54\u50b3\u64ad\uff0c\u4f8b\u5982\u5728\u79fb\u690d\u904e\u7a0b\u4e2d\u6216\u98df\u7528\u53d7\u6c61\u67d3\u7684\u8089\u985e\u3002<\/p><p>\u96d6\u7136\u76ee\u524d\u6b63\u5728\u7814\u7a76\u9019\u4e9b\u6b63\u5e38\u670a\u75c5\u6bd2\u86cb\u767d\u7684\u4f5c\u7528\uff0c\u4f46\u773e\u6240\u5468\u77e5\uff0c\u670a\u75c5\u6bd2\u86cb\u767d\u7684\u7570\u5e38\u6298\u758a\u6703\u5c0e\u81f4\u8166\u640d\u50b7\u548c\u75be\u75c5\u7684\u5178\u578b\u9ad4\u5fb5\u548c\u75c7\u72c0\u3002 \u670a\u75c5\u6bd2\u75c5\u5df2\u88ab\u8b49\u660e\u6703\u5c0e\u81f4\u4eba\u683c\u6539\u8b8a\u3001\u7126\u616e\u3001\u6291\u9b31\u548c\u8a18\u61b6\u529b\u6e1b\u9000\uff0c\u901a\u5e38\u5728\u5e7e\u500b\u6708\u5167\uff0c\u8a31\u591a\u4eba\u6703\u9677\u5165\u660f\u8ff7\u3002 \u670a\u75c5\u6bd2\u75be\u75c5\u901a\u5e38\u9032\u5c55\u8fc5\u901f\u4e26\u4e14\u7e3d\u662f\u81f4\u547d\u7684\uff0c\u4f46\u9019\u7a2e\u5feb\u901f\u7684\u795e\u7d93\u8b8a\u6027\u662f\u5982\u4f55\u767c\u751f\u7684\u4ecd\u7136\u6709\u9ede\u795e\u79d8\u3002<\/p><p>\u795e\u7d93\u5143\u4e2d\u53d7\u640d\u7c92\u7dda\u9ad4\u7684\u6301\u7e8c\u7a4d\u7d2f\u8207\u8870\u8001\u548c\u795e\u7d93\u9000\u884c\u6027\u75be\u75c5\u6709\u95dc\uff0c\u5305\u62ec\u670a\u75c5\u6bd2\u75c5\u3002 \u7c92\u7dda\u9ad4\u81ea\u566c\u662f\u7d30\u80de\u5167\u7c92\u7dda\u9ad4\u8cea\u91cf\u63a7\u5236\u9014\u5f91\u4e4b\u4e00\uff0c\u53ef\u4ee5\u9078\u64c7\u6027\u5730\u53bb\u9664\u53d7\u640d\u7c92\u7dda\u9ad4\uff0c\u9019\u53ef\u80fd\u8207\u670a\u75c5\u6bd2\u75c5\u4e2d\u53d7\u640d\u7c92\u7dda\u9ad4\u7684\u7a4d\u7d2f\u6709\u95dc\u3002 \u8a31\u591a\u7814\u7a76\u5831\u544a\u4e86 PINK1-parkin \u4f9d\u8cf4\u6027\u7c92\u7dda\u9ad4\u81ea\u566c\u901a\u8def\u5728\u795e\u7d93\u5143\u4e2d\u7684\u91cd\u8981\u6027\uff1aPINK1-parkin \u5f62\u6210\u4e86\u4e00\u7a2e\u4fe1\u865f\u8f49\u5c0e\u901a\u8def\uff0c\u53ef\u6a19\u8a18\u53d7\u640d\u7684\u7c92\u7dda\u9ad4\u4ee5\u9032\u884c\u6d88\u9664\u3002<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a4cfe8e elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"a4cfe8e\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img fetchpriority=\"high\" decoding=\"async\" width=\"550\" height=\"321\" src=\"https:\/\/cytologics.com\/wp-content\/uploads\/2022\/02\/912674_707970.jpg\" class=\"attachment-full size-full wp-image-8447\" alt=\"NMN\u53ef\u80fd\u5c0d\u7f55\u898b\u7684\u50b3\u67d3\u6027\u795e\u7d93\u9000\u884c\u6027\u75be\u75c5\u6709\u5e6b\u52a9\" \/><\/figure><div class=\"elementor-image-box-content\"><p class=\"elementor-image-box-description\">(McLelland et al., 2014 | The EMBO Journal) Parkin \u548c PINK1 \u5728\u8abf\u7bc0\u7c92\u7dda\u9ad4\u8cea\u91cf\u63a7\u5236\u4e2d\u8d77\u4f5c\u7528\u3002 \u4f5c\u70ba\u5c0d\u7c92\u7dda\u9ad4\u61c9\u6fc0\u7684\u53cd\u61c9\uff0cParkin \u8a98\u5c0e\u7c92\u7dda\u9ad4\u56ca\u6ce1\u7684 PINK1 \u4f9d\u8cf4\u6027\u5f62\u6210\uff0c\u9019\u4e9b\u56ca\u6ce1\u9776\u5411\u7a31\u70ba\u6eb6\u9176\u9ad4\u7684\u7d30\u80de\u7d50\u69cb\uff0c\u9019\u4e9b\u7d30\u80de\u7d50\u69cb\u5305\u88f9\u8457\u8ca8\u7269\u9032\u884c\u964d\u89e3\u3002 \u9019\u500b\u904e\u7a0b\u7a31\u70ba\u7c92\u7dda\u9ad4\u81ea\u566c\u3002\n<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1b611fe elementor-widget elementor-widget-text-editor\" data-id=\"1b611fe\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>NAD+ \u4fc3\u9032\u5291\u6539\u5584\u670a\u75c5\u6bd2\u75c5\u795e\u7d93\u5143\u7d30\u80de\u7684\u7dda\u7c92\u9ad4\u81ea\u566c<\/h3><div>\u00a0<\/div><p>\u00a0<\/p><p>\u7531\u65bc\u7c92\u7dda\u9ad4\u640d\u50b7\u662f\u795e\u7d93\u5143\u640d\u50b7\u7684\u65e9\u671f\u6307\u6a19\uff0c\u56e0\u6b64\u767c\u73fe\u7c92\u7dda\u9ad4\u81ea\u566c\u7f3a\u9677\u8207\u7c92\u7dda\u9ad4\u640d\u50b7\u4e4b\u9593\u7684\u95dc\u806f\u5c0d\u65bc\u670a\u75c5\u6bd2\u75be\u75c5\u7684\u65e9\u671f\u9810\u9632\u5177\u6709\u91cd\u8981\u610f\u7fa9\u3002 \u5728\u9019\u9805\u7814\u7a76\u4e2d\uff0cLi \u53ca\u5176\u540c\u4e8b\u7814\u7a76\u4e86\u670a\u75c5\u6bd2\u75be\u75c5\u7d30\u80de\u6a21\u578b\u4e2d\u53d7\u640d\u7684\u7c92\u7dda\u9ad4\u7a4d\u7d2f\u3002 \u5c0d\u65bc\u8a72\u6a21\u578b\uff0c\u5317\u4eac\u7684\u7814\u7a76\u5c0f\u7d44\u7528\u4e00\u7a2e\u5f71\u97ff\u670a\u75c5\u6bd2\u7684\u6709\u6bd2\u86cb\u767d\u8cea\u7247\u6bb5\u611f\u67d3\u5c0f\u9f20\u7684\u795e\u7d93\u5143\u7d30\u80de\uff0c\u7a31\u70ba\u670a\u75c5\u6bd2\u86cb\u767d 106-126 (PrP106-126)\u3002<\/p><p>\u00a0<\/p><p>\u00a0<\/p><p>\u9019\u7a2e\u4ecb\u5165\u5c0e\u81f4\u5927\u91cf\u7d30\u80de\u6b7b\u4ea1\uff0c\u4f7f\u6d3b\u529b\u964d\u4f4e 50-60%\u3002 \u6b64\u5916\uff0c\u7c92\u7dda\u9ad4\u660e\u986f\u788e\u7247\u5316\uff0c\u8868\u660e\u56b4\u91cd\u7684\u7c92\u7dda\u9ad4\u640d\u50b7\uff0cPINK1-Parkin \u4ecb\u5c0e\u7684\u7c92\u7dda\u9ad4\u81ea\u566c\u5df2\u5931\u6548\u4e14\u5e7e\u4e4e\u4e0d\u6d3b\u8e8d\u3002 \u4f46\u662f\u7576\u7528 NMN \u6cbb\u7642\u6642\uff0c\u670a\u75c5\u6bd2\u6a21\u578b\u795e\u7d93\u5143\u7d30\u80de\u88ab\u4fdd\u8b77\u514d\u65bc\u6b7b\u4ea1\u3002 \u76f8\u6bd4\u4e4b\u4e0b\uff0cUA \u4e0d\u80fd\u986f\u8457\u6e1b\u8f15 PrP106-126 \u8a98\u5c0e\u7684\u7d30\u80de\u6b7b\u4ea1\u3002<\/p><p>\u00a0<\/p><p>\u00a0<\/p><p>\u7576 Li \u53ca\u5176\u540c\u4e8b\u5c0d\u670a\u75c5\u6bd2\u6a21\u578b\u7684\u795e\u7d93\u5143\u7d30\u80de\u9032\u884c\u57fa\u56e0\u64cd\u4f5c\u4ee5\u7522\u751f\u904e\u91cf\u7684 Pink1 \u548c Parkin \u6642\uff0c\u7c92\u7dda\u9ad4\u81ea\u566c\u7f3a\u9677\u5f97\u5230\u7de9\u89e3\u3002 \u540c\u6a23\uff0c\u88dc\u5145\u5169\u7a2e\u7c92\u7dda\u9ad4\u81ea\u566c\u8a98\u5c0e\u5291\uff0c\u7159\u9170\u80fa\u55ae\u6838\u82f7\u9178 (NMN) \u6216\u5c3f\u77f3\u7d20 A (UA)\uff0c\u986f\u8457\u523a\u6fc0 PINK1-Parkin \u4ecb\u5c0e\u7684\u7c92\u7dda\u9ad4\u81ea\u566c\u3002 \u7136\u800c\uff0c\u8207 NMN \u76f8\u6bd4\uff0cUA \u4e26\u4e0d\u80fd\u7de9\u89e3\u670a\u75c5\u6bd2\u5f15\u8d77\u7684\u7c92\u7dda\u9ad4\u65b7\u88c2\u548c\u529f\u80fd\u969c\u7919\u3002\u3002<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9d2012f elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"9d2012f\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"1200\" height=\"625\" src=\"https:\/\/cytologics.com\/wp-content\/uploads\/2022\/02\/579444_793409.jpg\" class=\"attachment-full size-full wp-image-8448\" alt=\"NMN\u53ef\u80fd\u5c0d\u7f55\u898b\u7684\u50b3\u67d3\u6027\u795e\u7d93\u9000\u884c\u6027\u75be\u75c5\u6709\u5e6b\u52a9\" \/><\/figure><div class=\"elementor-image-box-content\"><p class=\"elementor-image-box-description\">(Li et al., 2022 | Cell Death & Disease) \u7528 NMN \u800c\u975e\u5c3f\u77f3\u7d20 A \u6fc0\u6d3b\u7c92\u7dda\u9ad4\u81ea\u566c\u53ef\u6e1b\u8f15\u6a21\u64ec\u670a\u75c5\u6bd2\u75c5\u7684\u795e\u7d93\u5143\u4e2d\u7684\u7d30\u80de\u6b7b\u4ea1\u3002 Li \u53ca\u5176\u540c\u4e8b\u6e2c\u8a66\u4e86 NMN \u548c\u5c3f\u77f3\u7d20 A (UA) \u5c0d\u6709\u6216\u6c92\u6709\u88ab\u670a\u75c5\u6bd2\u81f4\u75c5\u5291 (PrP106-126) \u611f\u67d3\u7684\u795e\u7d93\u5143\u7d30\u80de\u4e2d\u7c92\u7dda\u9ad4\u788e\u7247\u548c\u7d30\u80de\u6d3b\u529b\u7684\u5f71\u97ff\u3002\n<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-14594e9 elementor-widget elementor-widget-text-editor\" data-id=\"14594e9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>\u70ba\u4ec0\u9ebc\u662fNMN \u800c\u975e\u5c3f\u77f3\u7d20\u53ef\u4ee5\u4fdd\u8b77\u670a\u75c5\u6bd2\u75c5\u795e\u7d93\u5143\u514d\u65bc\u6b7b\u4ea1\uff1f<\/h3><div>\u00a0<\/div><p>Li \u53ca\u5176\u540c\u4e8b\u8868\u660e\uff0c\u53d7\u670a\u75c5\u6bd2\u75c5\u5f71\u97ff\u7684\u7d30\u80de\u5177\u6709\u56b4\u91cd\u7684\u7c92\u7dda\u9ad4\u65b7\u88c2\u548c\u529f\u80fd\u969c\u7919\u3002 \u7c92\u7dda\u9ad4\u81ea\u566c\u6fc0\u6d3b\u5291 NMN \u5728\u670a\u75c5\u6bd2\u75c5\u7d30\u80de\u6a21\u578b\u4e2d\u6fc0\u6d3b PINK1-Parkin \u4ecb\u5c0e\u7684\u7c92\u7dda\u9ad4\u81ea\u566c\u4e26\u6062\u5fa9\u7c92\u7dda\u9ad4\u5f62\u614b\u548c\u529f\u80fd\uff0c\u5f9e\u800c\u6e1b\u8f15 PrP106-126 \u8a98\u5c0e\u7684\u795e\u7d93\u5143\u7d30\u80de\u6b7b\u4ea1\u3002 NMN \u7684\u6cbb\u7642\u6548\u679c\u4e5f\u88ab\u5831\u5c0e\u5728\u5176\u4ed6\u75be\u75c5\u4e2d\uff0c\u4f8b\u5982\u8207\u904e\u65e9\u8870\u8001\u76f8\u95dc\u7684\u5171\u6fdf\u5931\u8abf\u6027\u6bdb\u7d30\u8840\u7ba1\u64f4\u5f35\u75c7\u548c\u8207\u9ad8\u8840\u58d3\u76f8\u95dc\u7684\u4e2d\u98a8\u3002<\/p><p>\u00a0<\/p><p>\u00a0<\/p><p>\u53e6\u4e00\u65b9\u9762\uff0c\u96d6\u7136 UA \u6fc0\u6d3b\u4e86\u7c92\u7dda\u9ad4\u81ea\u566c\uff0c\u4f46\u5b83\u4e26\u4e0d\u80fd\u6e1b\u8f15\u53d7\u670a\u75c5\u6bd2\u5f71\u97ff\u7684\u7d30\u80de\u53d7\u640d\u7684\u7c92\u7dda\u9ad4\u788e\u7247\u3002 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\u7531\u65bc\u5728\u5176\u4ed6\u75be\u75c5\uff08\u5982\u963f\u8328\u6d77\u9ed8\u75c5\u548c\u5e15\u91d1\u68ee\u75c5\u4ee5\u53ca\u5fc3\u808c\u75c5\uff09\u4e2d\u5df2\u7d93\u5831\u5c0e\u4e86\u9019\u7a2e\u7c92\u7dda\u9ad4\u81ea\u566c\u9014\u5f91\u7684\u7f3a\u9677\uff0c\u56e0\u6b64\u7c92\u7dda\u9ad4\u81ea\u566c\u6fc0\u6d3b\u5291\u53ef\u80fd\u5177\u6709\u5ee3\u6cdb\u7684\u6cbb\u7642\u6f5b\u529b\u3002 \u4e0d\u540c\u7684\u7c92\u7dda\u9ad4\u81ea\u566c\u6fc0\u6d3b\u5291\u53ef\u80fd\u66f4\u597d\u5730\u6cbb\u7642\u7279\u5b9a\u75be\u75c5\uff0c\u56e0\u6b64\u9700\u8981\u7be9\u9078\u5728\u6bcf\u7a2e\u7279\u5b9a\u75be\u75c5\u80cc\u666f\u4e0b\u4fc3\u9032\u7d30\u80de\u5065\u5eb7\u548c\u6d3b\u529b\u7684\u7c92\u7dda\u9ad4\u81ea\u566c\u6fc0\u6d3b\u5291\u3002<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b3b888a elementor-widget elementor-widget-text-editor\" data-id=\"b3b888a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u53c3\u8003\u6587\u737b:<\/p><p>Li J, Lai M, Zhang X, Li Z, Yang D, Zhao M, Wang D, Sun Z, Ehsan S, Li W, Gao H, Zhao D, Yang L. PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease. Cell Death Dis. 2022 Feb 18;13(2):162. doi: 10.1038\/s41419-022-04613-2. PMID: 35184140<\/p><p>\u00a0<\/p><p>\u6587\u7ae0\u4f86\u6e90:<\/p><p>https:\/\/www.nmn.com\/news\/nmn-neurodegenerative-disorder<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u7528\u7159\u9170\u80fa\u55ae\u6838\u82f7\u9178 (NMN) \u63d0\u9ad8 NAD+ \u6c34\u5e73\u53ef\u6539\u5584\u7531\u670a\u75c5\u6bd2\u75be\u75c5\u5f15\u8d77\u7684\u53d7\u640d\u7c92\u7dda\u9ad4\u7684\u6e05\u9664\u7f3a\u9677\uff0c\u5f9e\u800c\u4fdd\u8b77\u9019\u4e9b\u795e&#8230;<\/p>\n","protected":false},"author":1,"featured_media":8446,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[180],"tags":[],"class_list":["post-8443","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-180","nt-post-class","","excerpt-none"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-08-02 15:16:33","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"rttpg_featured_image_url":{"full":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/02\/579444_793409_2.jpg",672,416,false],"landscape":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/02\/579444_793409_2.jpg",672,416,false],"portraits":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/02\/579444_793409_2.jpg",672,416,false],"thumbnail":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/02\/579444_793409_2-150x150.jpg",150,150,true],"medium":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/02\/579444_793409_2-300x186.jpg",300,186,true],"large":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/02\/579444_793409_2.jpg",672,416,false],"1536x1536":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/02\/579444_793409_2.jpg",672,416,false],"2048x2048":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/02\/579444_793409_2.jpg",672,416,false],"trp-custom-language-flag":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/02\/579444_793409_2-18x12.jpg",18,12,true],"goldsmith-quickview":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/02\/579444_793409_2.jpg",60,37,false],"goldsmith-panel":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/02\/579444_793409_2.jpg",80,50,false],"goldsmith-mini":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/02\/579444_793409_2.jpg",300,186,false],"goldsmith-medium":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/02\/579444_793409_2.jpg",370,229,false],"goldsmith-square":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/02\/579444_793409_2.jpg",500,310,false],"goldsmith-grid":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/02\/579444_793409_2.jpg",672,416,false]},"rttpg_author":{"display_name":"nkcomys","author_link":"https:\/\/cytologics.com\/tc\/author\/nkcomys\/"},"rttpg_comment":0,"rttpg_category":"<a href=\"https:\/\/cytologics.com\/tc\/%e7%a7%91%e7%a0%94%e8%b3%87%e8%a8%8a\/\" rel=\"category tag\">\u79d1\u7814\u8cc7\u8a0a<\/a>","rttpg_excerpt":"\u7528\u7159\u9170\u80fa\u55ae\u6838\u82f7\u9178 (NMN) \u63d0\u9ad8 NAD+ \u6c34\u5e73\u53ef\u6539\u5584\u7531\u670a\u75c5\u6bd2\u75be\u75c5\u5f15\u8d77\u7684\u53d7\u640d\u7c92\u7dda\u9ad4\u7684\u6e05\u9664\u7f3a\u9677\uff0c\u5f9e\u800c\u4fdd\u8b77\u9019\u4e9b\u795e...","_links":{"self":[{"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/posts\/8443","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/comments?post=8443"}],"version-history":[{"count":39,"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/posts\/8443\/revisions"}],"predecessor-version":[{"id":17327,"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/posts\/8443\/revisions\/17327"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/media\/8446"}],"wp:attachment":[{"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/media?parent=8443"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/categories?post=8443"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/tags?post=8443"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}