{"id":8549,"date":"2021-10-15T22:16:19","date_gmt":"2021-10-15T14:16:19","guid":{"rendered":"https:\/\/www.cytologics.com.hk\/?p=8549"},"modified":"2024-05-18T16:30:41","modified_gmt":"2024-05-18T08:30:41","slug":"%e6%a2%85%e5%a5%a7%e8%a8%ba%e6%89%80%e7%a0%94%e7%a9%b6%e8%a1%a8%e6%98%8e%e8%84%8a%e9%ab%93%e7%a5%9e%e7%b6%93%e4%be%9d%e8%b3%b4%e6%96%bc-nad","status":"publish","type":"post","link":"https:\/\/cytologics.com\/tc\/%e6%a2%85%e5%a5%a7%e8%a8%ba%e6%89%80%e7%a0%94%e7%a9%b6%e8%a1%a8%e6%98%8e%e8%84%8a%e9%ab%93%e7%a5%9e%e7%b6%93%e4%be%9d%e8%b3%b4%e6%96%bc-nad\/","title":{"rendered":"\u7814\u7a76\u986f\u793a\u810a\u9ad3\u795e\u7d93\u4f9d\u8cf4\u65bc NAD+"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"8549\" class=\"elementor elementor-8549\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"gap-default elementor-section elementor-top-section elementor-element elementor-element-27c3e5a6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"27c3e5a6\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-393f0668\" data-id=\"393f0668\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6935219 elementor-widget elementor-widget-text-editor\" data-id=\"6935219\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h1>\u5728\u5c0f\u9f20\u4e2d\uff0c\u9ad8\u8102\u80aa\u98f2\u98df\u6703\u5c0e\u81f4\u7a31\u70ba\u9ad3\u9798\u7684\u50b3\u5c0e\u6027\u795e\u7d93\u5857\u5c64\u964d\u89e3\uff0c\u4f46\u5b83\u5011\u53ef\u4ee5\u901a\u904e\u524d\u9ad4 NMN \u6062\u5fa9 NAD+ \u6c34\u5e73\u4f86\u518d\u751f\u3002<\/h1>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-705d2d0e elementor-widget elementor-widget-text-editor\" data-id=\"705d2d0e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>By Jonathan D. Grinstein, Ph.D.<\/p><p>Published: 10:46 am PST Oct 11, 2021 | Updated: 1:53 p.m. PST Oct 15, 2021<\/p><p>\u00a0<\/p><h3>\u91cd\u5927\u4eae\u9ede<\/h3><p>\u00a0<\/p><div>\u2022\u9ad8\u8102\u80aa\u98f2\u98df\u6703\u964d\u4f4e\u5c0f\u9f20\u7684 NAD+ \u6c34\u5e73\uff0c\u5f9e\u800c\u5c0d\u7522\u751f\u9ad3\u9798\u7684\u7d30\u80de\uff08\u7a31\u70ba\u5be1\u7a81\u81a0\u8cea\u7d30\u80de\uff09\u7684\u5b58\u6d3b\u548c\u529f\u80fd\u7522\u751f\u4e0d\u5229\u5f71\u97ff\u3002<\/div><div>\u2022\u901a\u904e\u907a\u50b3\u6216\u57fa\u65bc\u85e5\u7269\u7684\u64cd\u4f5c\u6ec5\u6d3b CD38\uff08\u4e00\u7a2e NAD+ \u6d88\u8017\u9176\uff09\u53ef\u63d0\u9ad8\u5be1\u7a81\u81a0\u8cea\u7d30\u80de\u7684\u5b58\u6d3b\u7387\u3002<\/div><div>\u2022\u4f7f\u7528 NAD+ \u524d\u9ad4 NMN \u6062\u5fa9 NAD+ \u6c34\u5e73\u53ef\u9632\u6b62\u5be1\u7a81\u81a0\u8cea\u7d30\u80de\u4e1f\u5931\u4e26\u4fc3\u9032\u9ad3\u9798\u4fee\u5fa9\u3002<\/div><p>\u5c0d\u65bc\u6709\u610f\u8b58\u548c\u6f5b\u610f\u8b58\u7684\u4efb\u52d9\uff0c\u5f9e\u64c1\u62b1\u5230\u547c\u5438\uff0c\u6211\u5011\u7684\u795e\u7d93\u7cfb\u7d71\u9700\u8981\u4ee5\u9583\u96fb\u822c\u7684\u901f\u5ea6\u767c\u9001\u96fb\u4fe1\u865f\u3002 \u70ba\u4e86\u5be6\u73fe\u985e\u4f3c\u751f\u7269\u5149\u7e96\u7684\u50b3\u8f38\uff0c\u6211\u5011\u7a31\u70ba\u795e\u7d93\u5143\u7684\u795e\u7d93\u7d30\u80de\u5728\u9ad3\u9798\u4e2d\u7d55\u7de3\u2014\u2014\u9ad3\u9798\u662f\u4e00\u7a2e\u7528\u65bc\u5feb\u901f\u795e\u7d93\u901a\u8a0a\u7684\u5c0e\u96fb\u8986\u84cb\u7269\u3002 \u4f46\u662f\u7576\u9ad3\u9798\u88ab\u7834\u58de\u6642\uff0c\u96a8\u8457\u5e74\u9f61\u7684\u589e\u9577\u3001\u67d0\u4e9b\u907a\u50b3\u75be\u75c5\uff08\u5982\u591a\u767c\u6027\u786c\u5316\u75c7\uff09\u548c\u65b0\u9673\u4ee3\u8b1d\u4e0d\u826f\u800c\u767c\u751f\uff0c\u6211\u5011\u5c31\u5bb9\u6613\u53d7\u5230\u6c38\u4e45\u6027\u810a\u9ad3\u548c\u8166\u640d\u50b7\u7684\u5f71\u97ff\u3002 \u56e0\u6b64\uff0c\u6240\u6709\u7684\u901f\u98df\u548c\u4e0d\u904b\u52d5\u4e0d\u50c5\u4e0d\u5229\u65bc\u60a8\u7684\u65b0\u9673\u4ee3\u8b1d\uff1b \u5b83\u6703\u7834\u58de\u9ad3\u9798\u5857\u5c64\uff0c\u5f9e\u800c\u56b4\u91cd\u524a\u5f31\u65e5\u5e38\u751f\u6d3b\u4e2d\u5fc5\u4e0d\u53ef\u5c11\u7684\u795e\u7d93\u4fe1\u865f\u3002<\/p><p>\u00a0<\/p><p>\u767c\u8868\u5728\u5b78\u8853\u671f\u520a\u300a\u795e\u7d93\u79d1\u5b78\u300b(The Journal of Neuroscience)\u4e0a\u7684\u6885\u5967\u8a3a\u6240\u7684\u7814\u7a76\u8868\u660e\uff0c\u767d\u8cea\uff08\u9ad3\u9798\u5305\u88f9\u7684\u795e\u7d93\u6295\u5c04\u7a7f\u904e\u5927\u8166\u548c\u810a\u9ad3\u7684\u5730\u65b9\uff09\u6703\u56e0\u9ad8\u8102\u80aa\u6d88\u8017\u800c\u53d7\u640d\u3002 \u9019\u662f\u901a\u904e\u7834\u58de\u4e00\u7a2e\u7a31\u70ba\u7159\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 (NAD+) \u7684\u91cd\u8981\u4ee3\u8b1d\u8f14\u9176\u7684\u6c34\u5e73\u800c\u767c\u751f\u7684\uff0c\u5c0e\u81f4\u5c07\u9ad3\u78f7\u8102\u6dfb\u52a0\u5230\u795e\u7d93\u5143\u7684\u7d30\u80de\u2500\u2500\u5373\u7a31\u70ba\u5be1\u7a81\u81a0\u8cea\u7d30\u80de\u7684\u795e\u7d93\u7cfb\u7d71\u7d30\u80de\u55aa\u5931\u3002 \u4f46\u662f\u901a\u904e\u963b\u6b62 NAD+ \u7684\u6d88\u8017\u6216\u88dc\u5145\u524d\u9ad4\u7159\u9170\u80fa\u55ae\u6838\u82f7\u9178 (NMN) \u4f86\u589e\u52a0 NAD+ \u6c34\u5e73\uff0c\u53ef\u4ee5\u6e1b\u8f15\u5be1\u7a81\u81a0\u8cea\u7d30\u80de\u7684\u640d\u5931\u4e26\u4fc3\u9032\u9ad3\u9798\u518d\u751f\u3002<\/p><p>\u00a0<\/p><h3>\u98f2\u98df\u548c NAD+ \u8207\u591a\u767c\u6027\u786c\u5316\u75c7\u7684\u76f8\u95dc\u6027<\/h3><p>\u00a0<\/p><p>\u897f\u5f0f\u98f2\u98df\u6703\u7834\u58de\u7a31\u70ba\u5be1\u7a81\u81a0\u8cea\u7d30\u80de\u7684\u9ad3\u9798\u7d30\u80de\u548c\u7a31\u70ba\u661f\u5f62\u81a0\u8cea\u7d30\u80de\u7684\u652f\u6301\u7d30\u80de\u3002 \u80a5\u80d6\u662f\u591a\u767c\u6027\u786c\u5316\u75c7\u7684\u767c\u5c55\u3001\u9032\u7a0b\u548c\u5c0e\u81f4\u6b98\u75be\u7684\u95dc\u9375\u98a8\u96aa\u56e0\u7d20\uff0c\u591a\u767c\u6027\u786c\u5316\u75c7\u662f\u4e00\u7a2e\u514d\u75ab\u7cfb\u7d71\u4fb5\u8755\u9ad3\u9798\u7684\u75be\u75c5\uff0c\u7834\u58de\u4e86\u5927\u8166\u548c\u8eab\u9ad4\u4e4b\u9593\u7684\u4ea4\u6d41\u3002<\/p><p>\u00a0<\/p><p>CD38 \u662f\u795e\u7d93\u7cfb\u7d71\u4e2d\u4e3b\u8981\u7684 NAD+ \u6d88\u8017\u9176\uff0c\u5728\u591a\u767c\u6027\u786c\u5316\u75c7\u6a21\u578b\u4e2d\u6c34\u5e73\u5347\u9ad8\u3002 \u6539\u8b8a\u7684 NAD+ \u4ee3\u8b1d\u8207\u9ad8\u8102\u80aa\u6d88\u8017\u548c\u591a\u767c\u6027\u786c\u5316\u75c7\u6709\u95dc\u3002 \u6b64\u5916\uff0c\u6700\u8fd1\u7684\u5e7e\u9805\u7814\u7a76\u63a2\u7d22\u4e86\u88dc\u5145 NAD+ \u524d\u9ad4\u6216\u7a31\u70ba\u9ec3\u916e\u985e\u5316\u5408\u7269\u7684\u690d\u7269\u884d\u751f\u5316\u5408\u7269\uff0c\u9019\u4e9b\u5316\u5408\u7269\u5df2\u77e5\u53ef\u6291\u5236 NAD+ \u6d88\u8017\u9176\u963b\u7919\u9ad3\u9798\u4fee\u5fa9\u548c\u795e\u7d93\u4fdd\u8b77\u3002 \u4f8b\u5982\uff0cNAD+ \u524d\u9ad4\u88dc\u5145\u5291\u5728\u5404\u7a2e\u795e\u7d93\u75be\u75c5\u6a21\u578b\uff08\u5982\u4e2d\u98a8\u548c\u4ea8\u5ef7\u9813\u821e\u8e48\u75c7\uff09\u4e2d\u5177\u6709\u6cbb\u7642\u6027\u9ad3\u9798\u518d\u751f\u4f5c\u7528\u3002<\/p><p>\u00a0<\/p><p><strong>CD38 \u6c89\u9ed8\u7684\u5c0f\u9f20\u62b5\u6297\u9ad8\u8102\u80aa\u98f2\u98df\u5f15\u8d77\u7684\u5be1\u7a81\u81a0\u8cea\u7d30\u80de\u4e1f\u5931<\/strong><\/p><p>\u00a0<\/p><p>\u5728\u9019\u9805\u7814\u7a76\u4e2d\uff0cLangley\u548c\u6885\u5967\u8a3a\u6240\u7684\u540c\u4e8b\u5c07\u98f2\u98df\u3001\u9ad3\u78f7\u8102\u548c NAD+ \u806f\u7d50\u5728\u4e00\u8d77\u3002 \u4ed6\u5011\u767c\u73fe\uff0c\u5728\u6162\u6027\u9ad8\u8102\u80aa\u6d88\u8017\u3001\u812b\u9ad3\u9798\u640d\u50b7\u548c\u6d3b\u52d5\u6027\u591a\u767c\u6027\u786c\u5316\u6a23\u75c5\u8b8a\uff08\u810a\u9ad3\u548c\u5927\u8166\u4e2d\u7684\u640d\u50b7\u6216\u75a4\u75d5\uff08\u786c\u5316\uff09\u5340\u57df\uff09\u5f8c\uff0c\u5c0f\u9f20\u810a\u9ad3\u4e2d CD38 \u7684\u6c34\u5e73\u5347\u9ad8\uff0cNAD+\u7684 \u6c34\u5e73\u964d\u4f4e\u3002 \u4f46\u662f\uff0c\u57fa\u56e0\u6216\u6cbb\u7642\u5931\u53bb\u6d3b\u6027\u7684 CD38\u7684\u5c0f\u9f20\uff0c\u5728\u9ad8\u8102\u80aa\u8a98\u5c0e\u7684 NAD+ \u8017\u7aed\u548c\u5be1\u7a81\u81a0\u8cea\u7d30\u80de\u4e1f\u5931\u65b9\u9762\u5f97\u5230\u4e86\u986f\u8457\u7684\u4fdd\u8b77\u3002<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a4cfe8e elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"a4cfe8e\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img fetchpriority=\"high\" decoding=\"async\" width=\"702\" height=\"426\" src=\"https:\/\/cytologics.com\/wp-content\/uploads\/2021\/10\/747744_562746.jpg\" class=\"attachment-full size-full wp-image-8553\" alt=\"NAD+\" \/><\/figure><div class=\"elementor-image-box-content\"><p class=\"elementor-image-box-description\">\u6291\u5236 CD38 \u53ef\u963b\u6b62\u9ad8\u8102\u80aa\u98f2\u98df\u8a98\u5c0e\u7684\u5be1\u7a81\u81a0\u8cea\u7d30\u80de\u4e1f\u5931\u4e26\u4fc3\u9032\u9ad3\u9798\u4fee\u5fa9\u3002 \uff08\u5de6\u4e0a\uff09\u8207\u63a1\u7528\u5e38\u898f\u98f2\u98df (RD) \u7684\u975e\u8f49\u57fa\u56e0\u5c0f\u9f20\u7684 NAD+ \u6c34\u5e73\u76f8\u6bd4\uff0c\u63a1\u7528\u9ad8\u8102\u80aa\u98f2\u98df (HFD) \u7684\u5c0f\u9f20\u7684\u810a\u9ad3 NAD+ \u6c34\u5e73\u986f\u8457\u964d\u4f4e\u3002 \u7576 CD38 \u88ab\u57fa\u56e0\u6c89\u9ed8 (CD38ci) \u6642\uff0c\u7121\u8ad6\u98f2\u98df\u5982\u4f55\uff0c\u5c0f\u9f20\u7684 NAD+ \u6c34\u5e73\u90fd\u6703\u589e\u52a0\u3002 \uff08\u53f3\u4e0a\uff09\u5be1\u7a81\u81a0\u8cea\u7d30\u80de\u8b5c\u7cfb\u7684\u7d30\u80de\u689d\u5f62\u5716\uff1a\u65e9\u671f\uff08PDGFR\u03b1\uff0c\u7d05\u8272\uff09\u3001\u4e2d\u671f\uff08Olig2\uff0c\u9752\u8272\uff09\u548c\u6210\u719f\u5be1\u7a81\u81a0\u8cea\u7d30\u80de\u6a19\u8a18\u7269\uff08ASPA\uff0c\u7da0\u8272\uff09\u3002 CD38 \u6291\u5236\u5c0f\u9f20\u6062\u5fa9\u88ab\u9ad8\u8102\u80aa\u98f2\u98df\u7834\u58de\u7684\u5be1\u7a81\u81a0\u8cea\u7d30\u80de\u6c34\u5e73\u3002 \uff08\u5e95\u884c\uff09CD38 \u6291\u88fd\u5291 78c \u53ef\u6539\u5584\u810a\u9ad3\u5316\u5b78\u8a98\u5c0e\u812b\u9ad3\u9798 (LL) \u5f8c\u7684\u9ad3\u9798\u518d\u751f\u548c\u9ad3\u9798\u7d50\u5408\u86cb\u767d (MBP) \u6c34\u5e73\u3002\n<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1b611fe elementor-widget elementor-widget-text-editor\" data-id=\"1b611fe\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>NAD+ \u548c NMN \u5728\u8102\u80aa\u98fd\u548c\u57f9\u990a\u7269\u4e2d\u6062\u5fa9\u5be1\u7a81\u81a0\u8cea\u7d30\u80de\u5206\u5316<\/h3><p>\u00a0<\/p><p>\u70ba\u4e86\u6aa2\u67e5\u88dc\u5145 NAD+ \u6c34\u5e73\u5c0d\u795e\u7d93\u7cfb\u7d71\u7684\u5f71\u97ff\uff0cLangley \u53ca\u5176\u540c\u4e8b\u63a5\u4e0b\u4f86\u7528 NAD+ \u6216 NMN \u88dc\u5145\u5be1\u7a81\u81a0\u8cea\u7d30\u80de\u57f9\u990a\u7269\u3002 \u96d6\u7136\u55ae\u7368\u4f7f\u7528\u98fd\u548c\u8102\u80aa\u6703\u964d\u4f4e\u95dc\u9375\u5be1\u7a81\u81a0\u8cea\u7d30\u80de\u548c\u9ad3\u9798\u86cb\u767d\u7684\u6c34\u5e73\uff0c\u4f46\u8207 NAD+ \u6216 NMN \u5171\u540c\u8655\u7406\u5c07\u9019\u4e9b\u6c34\u5e73\u6062\u5fa9\u5230\u672a\u8655\u7406\u7d30\u80de\u7684\u6c34\u5e73\u3002 \u9019\u4e9b\u767c\u73fe\u8868\u660e\uff0c\u661f\u5f62\u81a0\u8cea\u7d30\u80de\u7684 CD38 \u7684\u589e\u52a0\u4ee5\u53ca\u76f8\u95dc\u7684 NAD+ \u6c34\u5e73\u7684\u6d88\u8017\uff0c\u53ef\u80fd\u901a\u904e\u708e\u75c7\u548c\u6c27\u5316\u61c9\u6fc0\uff0c\u9593\u63a5\u5c0e\u81f4\u5be1\u7a81\u81a0\u8cea\u7d30\u80de\u7684\u5065\u5eb7\u548c\u9ad3\u9798\u7684\u518d\u751f\u53d7\u640d\u3002<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9d2012f elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"9d2012f\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"576\" height=\"239\" src=\"https:\/\/cytologics.com\/wp-content\/uploads\/2021\/10\/888981_876808.jpg\" class=\"attachment-full size-full wp-image-8554\" alt=\"PLP &amp; MBP\" \/><\/figure><div class=\"elementor-image-box-content\"><p class=\"elementor-image-box-description\">\u88dc\u5145NAD+\u5c0d\u98fd\u548c\u8102\u80aa\u66b4\u9732\u7684\u5be1\u7a81\u81a0\u8cea\u7d30\u80de\u9ad3\u9798\u86cb\u767d\u7684\u76f4\u63a5\u5f71\u97ff\u3002 \u66b4\u9732\u65bc\u57f9\u990a\u76bf\u4e2d\u98fd\u548c\u8102\u80aa\u68d5\u6ada\u9178\u916f (PA) \u7684\u5be1\u7a81\u81a0\u8cea\u7d30\u80de\u964d\u4f4e\u4e86\u95dc\u9375\u5be1\u7a81\u81a0\u8cea\u7d30\u80de\u548c\u9ad3\u9798\u86cb\u767d PLP\uff08\u5de6\uff09\u548c MBP\uff08\u53f3\uff09\u7684\u6c34\u5e73\u3002 \u88dc\u5145 NMN \u4f7f PLP \u548c MBP \u7684\u6c34\u5e73\u6062\u5fa9\u5230\u672a\u8655\u7406\u7684\u5be1\u7a81\u81a0\u8cea\u7d30\u80de\u7684\u6c34\u5e73\u3002 NMN \u7684\u4f5c\u7528\u88ab SIRT1 \u6291\u88fd\u5291\u963b\u65b7\uff0cSIRT1 \u662f\u4e00\u7a2e\u4f9d\u8cf4\u65bc NAD+ \u7684\u9176\uff0c\u5c0d\u7d30\u80de\u5065\u5eb7\u548c\u5b58\u6d3b\u81f3\u95dc\u91cd\u8981\uff0c\u7a31\u70ba EX527\u3002\n<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-14594e9 elementor-widget elementor-widget-text-editor\" data-id=\"14594e9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u4ed6\u5011\u9084\u8868\u793a\uff0c\u9019\u4e9b\u7814\u7a76\u662f\u672a\u4f86\u7814\u7a76\u7684\u57fa\u790e\uff0c\u4ee5\u95e1\u660e\u98f2\u98df\u5728\u767c\u80b2\u548c\u8870\u8001\u904e\u7a0b\u4e2d\u5c0d\u5be1\u7a81\u81a0\u8cea\u7d30\u80de\u7684\u4f5c\u7528\u3002<\/p><p>\u00a0<\/p><p>\u9019\u4e9b\u767c\u73fe\u5171\u540c\u6307\u51fa\u4e86\u9776\u5411 CD38 \u4ee5\u6539\u5584\u591a\u767c\u6027\u786c\u5316\u75c7\u548c\u5176\u4ed6\u812b\u9ad3\u9798\u75be\u75c5\u7684\u7d50\u679c\u7684\u6f5b\u5728\u8f49\u5316\u50f9\u503c\u3002<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-52d1439 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"52d1439\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"669\" height=\"288\" src=\"https:\/\/cytologics.com\/wp-content\/uploads\/2021\/10\/259969_919287.jpg\" class=\"attachment-full size-full wp-image-8555\" alt=\"Myelin repair\" \/><\/figure><div class=\"elementor-image-box-content\"><p class=\"elementor-image-box-description\">\u7531\u651d\u5165\u9ad8\u8102\u80aa\u98f2\u98df\u5f15\u767c\u7684\u4ee3\u8b1d\u7d0a\u4e82\u901a\u904e\u661f\u5f62\u81a0\u8cea\u7d30\u80de\u76f8\u95dc\u7684\u9593\u63a5 NAD+ \u4f9d\u8cf4\u6027\u6a5f\u5236\u4fc3\u9032\u5be1\u7a81\u81a0\u8cea\u7d30\u80de\u4e1f\u5931\u4e26\u640d\u5bb3\u9ad3\u9798\u518d\u751f\u3002 \u975c\u606f\u661f\u5f62\u81a0\u8cea\u7d30\u80de\u901a\u5e38\u6709\u52a9\u65bc\u5728\u5fc5\u8981\u6642\u70ba\u5be1\u7a81\u81a0\u8cea\u7d30\u80de\u5206\u5316\u548c\u4fee\u5fa9\u63d0\u4f9b\u652f\u6301\u74b0\u5883\u3002 \u9ad8\u8102\u80aa\u98f2\u98df (HFD) \u548c\u6eb6\u8840\u5375\u78f7\u8102 (LL) \u6703\u589e\u52a0\u53cd\u61c9\u6027\u661f\u5f62\u81a0\u8cea\u7d30\u80de\u4e2d CD38 \u7684\u8868\u9054\uff0c\u5f9e\u800c\u6d88\u8017 NAD+ \u6c34\u5e73\u3002 NAD+ \u7684\u6e1b\u5c11\u6703\u89f8\u767c\u5be1\u7a81\u81a0\u8cea\u7d30\u80de\u8b5c\u7cfb\u7d30\u80de\u7684\u5206\u5316\u548c\u5b58\u6d3b\u53d7\u640d\u3002 CD38 \u6291\u88fd\u5291 78c \u6291\u5236\u5c0d\u5be1\u7a81\u81a0\u8cea\u7d30\u80de\u7684\u4e0d\u5229\u5f71\u97ff\u4e26\u6539\u5584\u9ad3\u9798\u4fee\u5fa9\u3002\n<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b3b888a elementor-widget elementor-widget-text-editor\" data-id=\"b3b888a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u53c3\u8003\u6587\u737b:<\/p><p>\u00a0<\/p><p>Langley MR, Choi CI, Peclat TR, Guo Y, Simon W, Yoon H, Kleppe L, Lucchinetti CF, Chini CCS, Chini EN, Scarisbrick IA. Critical Role of Astrocyte NAD+ Glycohydrolase in Myelin Injury and Regeneration. J Neurosci. 2021 Sep 7:JN-RM-2264-20. doi: 10.1523\/JNEUROSCI.2264-20.2021. Epub ahead of print. PMID: 34493542<\/p><p>\u00a0<\/p><p>\u6587\u7ae0\u4f86\u6e90:<\/p><p>\u00a0<\/p><p>https:\/\/www.nmn.com\/news\/mayo-clinic-spinal-cord-nerve-projection-health-nad<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u5728\u5c0f\u9f20\u4e2d\uff0c\u9ad8\u8102\u80aa\u98f2\u98df\u6703\u5c0e\u81f4\u7a31\u70ba\u9ad3\u9798\u7684\u50b3\u5c0e\u6027\u795e\u7d93\u5857\u5c64\u964d\u89e3\uff0c\u4f46\u5b83\u5011\u53ef\u4ee5\u901a\u904e\u524d\u9ad4 NMN \u6062\u5fa9 NAD+ \u6c34\u5e73\u4f86\u518d\u751f&#8230;<\/p>\n","protected":false},"author":1,"featured_media":8550,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[180],"tags":[],"class_list":["post-8549","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-180","nt-post-class","","excerpt-none"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-08-23 21:10:21","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"rttpg_featured_image_url":{"full":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/910091_993672.jpg",747,451,false],"landscape":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/910091_993672.jpg",747,451,false],"portraits":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/910091_993672.jpg",747,451,false],"thumbnail":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/910091_993672-150x150.jpg",150,150,true],"medium":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/910091_993672-300x181.jpg",300,181,true],"large":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/910091_993672.jpg",747,451,false],"1536x1536":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/910091_993672.jpg",747,451,false],"2048x2048":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/910091_993672.jpg",747,451,false],"trp-custom-language-flag":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/910091_993672-18x12.jpg",18,12,true],"goldsmith-quickview":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/910091_993672.jpg",60,36,false],"goldsmith-panel":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/910091_993672.jpg",80,48,false],"goldsmith-mini":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/910091_993672.jpg",300,181,false],"goldsmith-medium":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/910091_993672.jpg",370,223,false],"goldsmith-square":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/910091_993672.jpg",500,302,false],"goldsmith-grid":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/910091_993672.jpg",747,451,false]},"rttpg_author":{"display_name":"nkcomys","author_link":"https:\/\/cytologics.com\/tc\/author\/nkcomys\/"},"rttpg_comment":0,"rttpg_category":"<a href=\"https:\/\/cytologics.com\/tc\/%e7%a7%91%e7%a0%94%e8%b3%87%e8%a8%8a\/\" rel=\"category tag\">\u79d1\u7814\u8cc7\u8a0a<\/a>","rttpg_excerpt":"\u5728\u5c0f\u9f20\u4e2d\uff0c\u9ad8\u8102\u80aa\u98f2\u98df\u6703\u5c0e\u81f4\u7a31\u70ba\u9ad3\u9798\u7684\u50b3\u5c0e\u6027\u795e\u7d93\u5857\u5c64\u964d\u89e3\uff0c\u4f46\u5b83\u5011\u53ef\u4ee5\u901a\u904e\u524d\u9ad4 NMN \u6062\u5fa9 NAD+ \u6c34\u5e73\u4f86\u518d\u751f...","_links":{"self":[{"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/posts\/8549","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/comments?post=8549"}],"version-history":[{"count":16,"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/posts\/8549\/revisions"}],"predecessor-version":[{"id":17330,"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/posts\/8549\/revisions\/17330"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/media\/8550"}],"wp:attachment":[{"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/media?parent=8549"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/categories?post=8549"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/tags?post=8549"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}