{"id":9029,"date":"2021-06-18T00:33:51","date_gmt":"2021-06-17T16:33:51","guid":{"rendered":"https:\/\/www.cytologics.com.hk\/?p=9029"},"modified":"2024-05-18T16:26:07","modified_gmt":"2024-05-18T08:26:07","slug":"12-%e9%80%b1%e7%9a%84-nmn-%e8%a3%9c%e5%85%85%e5%8a%91%e5%8f%af%e6%94%b9%e5%96%84%e4%ba%ba%e9%ab%94%e7%9a%84%e8%82%8c%e8%82%89%e5%8a%9f%e8%83%bd","status":"publish","type":"post","link":"https:\/\/cytologics.com\/tc\/12-%e9%80%b1%e7%9a%84-nmn-%e8%a3%9c%e5%85%85%e5%8a%91%e5%8f%af%e6%94%b9%e5%96%84%e4%ba%ba%e9%ab%94%e7%9a%84%e8%82%8c%e8%82%89%e5%8a%9f%e8%83%bd\/","title":{"rendered":"12 \u9031\u7684 NMN \u88dc\u5145\u5291\u53ef\u6539\u5584\u4eba\u9ad4\u7684\u808c\u8089\u529f\u80fd"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"9029\" class=\"elementor elementor-9029\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"gap-default elementor-section elementor-top-section elementor-element elementor-element-27c3e5a6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"27c3e5a6\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-393f0668\" data-id=\"393f0668\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6935219 elementor-widget elementor-widget-text-editor\" data-id=\"6935219\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h1>\u4e00\u9805\u91dd\u5c0d\u8001\u5e74\u7537\u6027\u7684\u81e8\u5e8a\u7814\u7a76\u9996\u6b21\u8868\u660e\uff0c\u670d\u7528 NMN \u6703\u589e\u52a0\u8840\u6db2 NAD+ \u6c34\u5e73\u4e26\u6539\u5584\u808c\u8089\u529b\u91cf\u548c\u6027\u80fd\u7684\u5404\u7a2e\u6307\u6a19\u3002<\/h1>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-705d2d0e elementor-widget elementor-widget-text-editor\" data-id=\"705d2d0e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>By Brett J. Weiss<\/p><p>Published: 2:12 p.m. PST Jun 18, 2021 | Updated: 4:42 p.m. PST Jun 18, 2021<\/p><p>\u00a0<\/p><h3>\u91cd\u5927\u4eae\u9ede<\/h3><p>\u00a0<\/p><div>\u2022NMN \u63d0\u9ad8 65 \u6b72\u4ee5\u4e0a\u7537\u6027\u7684\u8840\u6db2 NAD+ \u548c NAD+ \u4ee3\u8b1d\u7269\u6c34\u5e73\u3002<\/div><div>\u202212 \u9031\u5167\u88dc\u5145 250 \u6beb\u514b NMN \u53ef\u589e\u5f37\u808c\u8089\u529f\u80fd\u548c\u6d3b\u52d5\u80fd\u529b\u3002<\/div><div>\u00a0<\/div><div><p>\u52d5\u7269\u7814\u7a76\u986f\u793a\uff0c\u7d66\u4e88\u524d\u9ad4\u5206\u5b50\u7159\u9170\u80fa\u55ae\u6838\u82f7\u9178 (NMN) \u53ef\u63d0\u9ad8\u7159\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 (NAD+) \u6c34\u5e73\u3002 \u6709\u8da3\u7684\u662f\uff0c\u8207\u5e74\u9f61\u76f8\u95dc\u7684 NAD+ \u6c34\u5e73\u964d\u4f4e\u8207\u5fc3\u8840\u7ba1\u3001\u795e\u7d93\u9000\u884c\u6027\u75be\u75c5\u548c\u4ee3\u8b1d\u75be\u75c5\u4ee5\u53ca\u808c\u8089\u529f\u80fd\u964d\u4f4e\u6709\u95dc\uff0c\u88dc\u5145 NMN \u53ef\u4ee5\u6539\u5584\u9019\u7a2e\u60c5\u6cc1\u2014\u2014\u81f3\u5c11\u5728\u56d3\u9f52\u52d5\u7269\u4e2d\u662f\u9019\u6a23\u3002 \u90a3\u9ebc\uff0c\u6211\u5011\u5982\u4f55\u78ba\u5b9a\u88dc\u5145 NMN \u662f\u5426\u6709\u52a9\u65bc\u6cbb\u7642\u4eba\u985e\u9019\u4e9b\u8207\u5e74\u9f61\u76f8\u95dc\u7684\u75be\u75c5\uff1f<\/p><p>\u00a0<\/p><p>\u6771\u4eac\u5927\u5b78\u7684 Yamauchi \u53ca\u5176\u540c\u4e8b\u5728 Research Square \u4e0a\u767c\u8868\u4e86\u4e00\u7bc7\u975e\u540c\u884c\u8a55\u5be9\u671f\u520a\u8ad6\u6587\uff0c\u8868\u660e\u6bcf\u5929\u53e3\u670d 250 \u6beb\u514b NMN \u5c0d 65 \u6b72\u4ee5\u4e0a\u7537\u6027\u9032\u884c\u53e3\u670d\u4ecb\u5165\uff0c\u53ef\u986f\u8457\u63d0\u9ad8\u4ed6\u5011\u7684 NAD+ \u6c34\u5e73\u4e26\u6539\u5584\u4ed6\u5011\u7684\u808c\u8089\u8868\u73fe\u3002 \u5177\u9ad4\u4f86\u8aaa\uff0c\u88dc\u5145 NMN \u589e\u52a0\u4e86\u4ed6\u5011\u5728 30 \u79d2\u5167\u5f9e\u6905\u5b50\u4e0a\u7ad9\u8d77\u4f86\u7684\u6b21\u6578\uff0c\u63d0\u9ad8\u4e86\u6b65\u884c\u901f\u5ea6\uff0c\u4e26\u63d0\u9ad8\u4e86\u63e1\u529b\u3002 \u8a72\u7814\u7a76\u7684\u7d50\u679c\u589e\u52a0\u4e86\u66f4\u591a\u8b49\u64da\uff0c\u8b49\u660e NMN \u5728\u56d3\u9f52\u985e\u52d5\u7269\u7b49\u52d5\u7269\u8eab\u4e0a\u770b\u5230\u7684\u5065\u5eb7\u8870\u8001\u76ca\u8655\u5f97\u4ee5\u8f49\u5316\u70ba\u4eba\u985e\u3002<\/p><p>\u00a0<\/p><h3>\u670d\u7528 NMN 12 \u9031\u7684\u8010\u53d7\u6027\u826f\u597d<\/h3><p>\u00a0<\/p><p>\u5728 Yamauchi \u53ca\u5176\u540c\u4e8b\u6e2c\u8a66 NMN \u5728\u6539\u5584\u8001\u5e74\u7537\u6027\u808c\u8089\u529f\u80fd\u65b9\u9762\u7684\u6548\u679c\u4e4b\u524d\uff0c\u7814\u7a76\u5c0f\u7d44\u60f3\u77e5\u9053\u670d\u7528\u5b83\u662f\u5426\u5b89\u5168\u3002 \u7814\u7a76\u5c0f\u7d44\u7814\u7a76\u4e86\u8868\u660e\u6bd2\u6027\u7684\u5e38\u898b\u8840\u6db2\u5316\u5b78\u6e2c\u91cf\u503c\uff0c\u5305\u62ec\u6bcf\u5929\u4f7f\u7528 NMN 12 \u9031\u5f8c\u7684\u809d\u9176\u548c\u814e\u529f\u80fd\u6a19\u8a8c\u7269\u3002 \u91cd\u8981\u7684\u662f\uff0c\u8207\u672a\u670d\u7528 NMN \u7684\u7537\u6027\u76f8\u6bd4\uff0c\u670d\u7528 NMN \u7684\u7537\u6027\u7d44\u7684\u5be6\u9a57\u5ba4\u7d50\u679c\u6c92\u6709\u6539\u8b8a\uff0c\u9019\u8868\u660e\u670d\u7528 NMN \u7684\u8010\u53d7\u6027\u826f\u597d\u3002<\/p><p>\u00a0<\/p><h3>\u53e3\u670d NMN \u589e\u52a0\u4eba\u985e\u7684 NAD+ \u6c34\u5e73<\/h3><p>\u00a0<\/p><p>\u7531\u65bc\u4e4b\u524d\u7684\u7814\u7a76\u8868\u660e\u88dc\u5145 NMN \u6703\u589e\u52a0\u8001\u5e74\u56d3\u9f52\u52d5\u7269\u7684\u8840\u6db2 NAD+ \u6c34\u5e73\uff0c\u4e26\u4e14\u9019\u4e9b\u8f03\u9ad8\u7684 NAD+ \u6c34\u5e73\u8207\u75be\u75c5\u72c0\u6cc1\u7684\u6539\u5584\u76f8\u95dc\uff0c\u56e0\u6b64 Yamauchi \u53ca\u5176\u540c\u4e8b\u6e2c\u8a66\u4e86 NMN \u88dc\u5145\u5291\u662f\u5426\u6703\u589e\u52a0\u8001\u5e74\u7537\u6027\u7684 NAD+\u3002 \u4ed6\u5011\u767c\u73fe\uff0c12 \u9031\u7684 NMN \u88dc\u5145\u5291\u986f\u8457\u589e\u52a0\u4e86\u8840\u6db2 NAD+ \u6c34\u5e73\uff0c\u9019\u662f\u4efb\u4f55\u7814\u7a76\u7684\u7b2c\u4e00\u500b\u7d50\u679c\uff0c\u8868\u660e NMN \u589e\u52a0\u4e86\u4eba\u985e\u7684\u8840\u6db2 NAD+\u3002<\/p><\/div><p>\u00a0<\/p><p>\u9032\u4e00\u6b65\u7684\u5206\u6790\u8868\u660e\uff0cNMN \u88dc\u5145\u5291\u901a\u904e\u4fc3\u9032 NMN \u8f49\u5316\u70ba NAD+ \u4ee5\u53ca\u5176\u4ed6 NMN \u4ee3\u8b1d\u7269\uff0c\u901a\u904e\u55ae\u7368\u7684 NAD+ \u5408\u6210\u9014\u5f91\uff08\u5f9e\u982d\u9014\u5f91\uff09\u8f49\u5316\u70ba NAD+ \u4f86\u6539\u5584 NAD+ \u4ee3\u8b1d\u3002 \u9019\u4e9b\u767c\u73fe\u958b\u555f\u4e86 NMN \u901a\u904e\u6fc0\u6d3b\u4e0d\u6b62\u4e00\u7a2e NAD+ \u751f\u7269\u5408\u6210\u9014\u5f91\u4f86\u9a45\u52d5 NAD+ \u751f\u7522\u7684\u53ef\u80fd\u6027\u3002<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a4cfe8e elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"a4cfe8e\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img fetchpriority=\"high\" decoding=\"async\" width=\"548\" height=\"205\" src=\"https:\/\/cytologics.com\/wp-content\/uploads\/2021\/06\/Picture-1.png\" class=\"attachment-full size-full wp-image-9035\" alt=\"12 \u9031\u7684 NMN \u88dc\u5145\u5291\u53ef\u6539\u5584\u4eba\u9ad4\u7684\u808c\u8089\u529f\u80fd\" \/><\/figure><div class=\"elementor-image-box-content\"><p class=\"elementor-image-box-description\">(Igarashi et al., 2021 | Research Square) \u670d\u7528 NMN \u6703\u986f\u8457\u589e\u52a0\u8840\u6db2 NMN \u548c NAD+ \u6c34\u5e73\u3002 \u6bcf\u5929\u88dc\u5145 NMN 12 \u9031\u5f8c\uff0c\u8840\u6db2 NMN \u6c34\u5e73\u986f\u8457\u5347\u9ad8 (A)\uff0cNAD+ \u6c34\u5e73\u986f\u8457\u5347\u9ad8 (B)\u3002 \u9019\u4e9b\u767c\u73fe\u9996\u6b21\u8868\u660e\u9577\u671f\u670d\u7528 NMN \u6703\u589e\u52a0\u4eba\u7684\u8840\u6db2 NAD+ \u6c34\u5e73\u3002\n<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1b611fe elementor-widget elementor-widget-text-editor\" data-id=\"1b611fe\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>NMN \u589e\u5f37 65 \u6b72\u53ca\u4ee5\u4e0a\u7537\u6027\u7684\u808c\u8089\u8868\u73fe<\/h3><p>\u00a0<\/p><p>\u70ba\u4e86\u627e\u51fa\u9019\u4e9b NMN \u8a98\u5c0e\u7684 NAD+ \u6c34\u5e73\u5347\u9ad8\u662f\u5426\u6703\u6539\u5584\u8eab\u9ad4\u6a5f\u80fd\uff0cYamauchi\u53ca\u5176\u540c\u4e8b\u6e2c\u8a66\u4e86\u808c\u8089\u529b\u91cf\u548c\u8868\u73fe\u3002 \u4ed6\u5011\u767c\u73fe NMN \u986f\u8457\u6539\u5584\u4e86\u808c\u8089\u529b\u91cf\u548c\u8868\u73fe\u7684\u5e7e\u500b\u6307\u6a19\uff1a\u6b65\u884c\u901f\u5ea6\u3001\u63e1\u529b\u4ee5\u53ca\u53c3\u8207\u8005\u5728 30 \u79d2\u5167\u5f9e\u6905\u5b50\u4e0a\u7ad9\u8d77\u4f86\u7684\u6b21\u6578\u3002 \u4ed6\u5011\u7684\u7d50\u679c\u8868\u660e\uff0c\u53e3\u670d NMN \u88dc\u5145\u5291 12\u9031\u53ef\u6539\u5584\u5065\u5eb7\u8001\u5e74\u7537\u6027\u7684\u808c\u8089\u529b\u91cf\u548c\u8868\u73fe\u3002<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9d2012f elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"9d2012f\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"944\" height=\"594\" src=\"https:\/\/cytologics.com\/wp-content\/uploads\/2021\/06\/138835_898501.jpg\" class=\"attachment-full size-full wp-image-9034\" alt=\"12 \u9031\u7684 NMN \u88dc\u5145\u5291\u53ef\u6539\u5584\u4eba\u9ad4\u7684\u808c\u8089\u529f\u80fd\" \/><\/figure><div class=\"elementor-image-box-content\"><p class=\"elementor-image-box-description\">(Igarashi et al., 2021 | Research Square) \u6bcf\u5929\u670d\u7528 NMN 12 \u9031\u53ef\u986f\u8457\u63d0\u9ad8\u6b65\u884c\u901f\u5ea6\u3001\u63e1\u529b\u4ee5\u53ca 30 \u79d2\u5167\u5f9e\u6905\u5b50\u4e0a\u8d77\u8eab\u7684\u6b21\u6578\u3002 \u5982\u5de6\u4e0a\u8c61\u9650\u6240\u793a\uff0c\u4ee5\u7c73\/\u79d2\u70ba\u55ae\u4f4d\u7684\u6b65\u884c\u901f\u5ea6\uff08\u6b65\u614b\u901f\u5ea6\uff09\u5927\u5e45\u589e\u52a0\u3002 \u5de6\u4e0b\u8c61\u9650\u986f\u793a\uff0c\u5728\u88dc\u5145 NMN \u516d\u9031\u5f8c\uff0c30 \u79d2\u5167\u5f9e\u6905\u5b50\u4e0a\u7ad9\u8d77\u4f86\u7684\u6b21\u6578\uff0830 \u79d2\u6905\u67b6\u6e2c\u8a66\uff09\u986f\u8457\u589e\u52a0\u3002 \u53f3\u4e0b\u8c61\u9650\u4e2d\u986f\u793a\u7684\u5de6\u624b\u63e1\u529b\u4e5f\u96a8\u8457 NMN \u7684\u88dc\u5145\u800c\u986f\u8457\u589e\u52a0\u3002 \u9019\u4e9b\u767c\u73fe\u8868\u660e NMN \u53ef\u6539\u5584\u808c\u8089\u904b\u52d5\u548c\u529f\u80fd\u3002\n<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-14594e9 elementor-widget elementor-widget-text-editor\" data-id=\"14594e9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>NMN \u5982\u4f55\u6539\u5584\u808c\u8089\u529f\u80fd\uff1f<\/h3><p>\u00a0<\/p><p>\u5118\u7ba1\u9019\u4e9b\u767c\u73fe\u8868\u660e\u9577\u671f\u88dc\u5145 NMN \u53ef\u4fc3\u9032\u6574\u9ad4\u808c\u8089\u5065\u5eb7\uff0c\u4f46\u6c92\u6709\u8b49\u64da\u986f\u793a\u9019\u4e00\u5207\u662f\u5982\u4f55\u8d77\u4f5c\u7528\u7684\u3002 \u66f4\u91cd\u8981\u7684\u662f\uff0c\u9019\u9805\u7814\u7a76\u662f\u5728\u4e00\u5c0f\u7fa4\u5065\u5eb7\u7684\u8001\u5e74\u7537\u6027\u4e2d\u9032\u884c\u7684\u3002 \u70ba\u4e86\u66f4\u78ba\u5b9a NMN \u53ef\u4ee5\u63d0\u9ad8 NAD+ \u6c34\u5e73\u4e26\u6539\u5584\u4eba\u9ad4\u808c\u8089\u529b\u91cf\u548c\u8868\u73fe\u7684\u4e3b\u8981\u7d50\u8ad6\uff0c\u9019\u4e9b\u7814\u7a76\u9700\u8981\u5728\u5305\u62ec\u5973\u6027\u5728\u5167\u7684\u66f4\u5927\u7684\u6210\u5e74\u4eba\u7fa4\u4e2d\u9032\u884c\u8907\u88fd\u3002 \u5118\u7ba1\u5982\u6b64\uff0c\u5c0d\u65bc NMN \u88ab\u8a8d\u70ba\u662f\u4e00\u7a2e\u81e8\u5e8a\u8b49\u660e\u7684\u6297\u8870\u8001\u5291\uff0c\u9019\u662f\u671d\u8457\u6b63\u78ba\u65b9\u5411\u9081\u51fa\u7684\u4e00\u6b65\uff0c\u56e0\u70ba\u9019\u9805\u7814\u7a76\u662f\u4e00\u500b\u6709\u5e0c\u671b\u7684\u6307\u6a19\uff0c\u8868\u660e\u5728\u56d3\u9f52\u985e\u52d5\u7269\u4e2d\u770b\u5230\u7684 NMN \u7684\u4e00\u4e9b\u6297\u8870\u8001\u4f5c\u7528\u53ef\u80fd\u6703\u64f4\u5c55\u5230\u4eba\u985e\u3002<\/p><p>\u00a0<\/p><p>\u66f4\u91cd\u8981\u7684\u662f\uff0c\u6bcf\u5929 250 \u6beb\u514b\u7684\u5291\u91cf\u5df2\u61c9\u7528\u65bc\u53e6\u4e00\u9805\u7814\u7a76\uff0c\u8868\u660e NMN \u53ef\u6539\u5584\u8001\u5e74\u5973\u6027\u7684\u808c\u8089\u80f0\u5cf6\u7d20\u654f\u611f\u6027\u3002 \u56e0\u6b64\uff0c\u6bcf\u5929 250 \u6beb\u514b\u53ef\u80fd\u5c0d\u8001\u5e74\u4eba\u6709\u6548\uff0c\u4f46\u4e00\u9805\u91dd\u5c0d\u65e5\u672c\u7537\u6027\u7684\u7814\u7a76\u8868\u660e\uff0c\u9ad8\u9054 500 \u6beb\u514b\u7684\u8010\u53d7\u6027\u826f\u597d\u3002 \u56e0\u6b64\uff0c\u554f\u984c\u4ecd\u7136\u662f\u5b89\u5168\u8010\u53d7\u7684\u66f4\u9ad8\u5291\u91cf\u662f\u5426\u53ef\u4ee5\u770b\u5230\u9032\u4e00\u6b65\u7684\u76ca\u8655\u3002<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b3b888a elementor-widget elementor-widget-text-editor\" data-id=\"b3b888a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u53c3\u8003\u6587\u737b:<\/p><p>\u00a0<\/p><p>Wu S, Zhang R. CD38-expressing macrophages drive age-related NAD+ decline. Nat Metab. 2020 Nov;2(11):1186-1187. doi: 10.1038\/s42255-020-00292-5. PMID: 33199923<\/p><p>\u00a0<\/p><p>\u5f15\u7528\u6587\u737b:<\/p><p>\u00a0<\/p><p>Chini CCS, Peclat TR, Warner GM, Kashyap S, Espindola-Netto JM, de Oliveira GC, Gomez LS, Hogan KA, Tarrag\u00f3 MG, Puranik AS, Agorrody G, Thompson KL, Dang K, Clarke S, Childs BG, Kanamori KS, Witte MA, Vidal P, Kirkland AL, De Cecco M, Chellappa K, McReynolds MR, Jankowski C, Tchkonia T, Kirkland JL, Sedivy JM, van Deursen JM, Baker DJ, van Schooten W, Rabinowitz JD, Baur JA, Chini EN. CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels. Nat Metab. 2020 Nov;2(11):1284-1304. doi: 10.1038\/s42255-020-00298-z. Epub 2020 Nov 16. PMID: 33199925<\/p><p>\u00a0<\/p><p>Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin KO, Lee YM, Riley R, Ben-Sahra I, Ott M, Schilling B, Scheibye-Knudsen M, Ishihara K, Quake SR, Newman J, Brenner C, Campisi J, Verdin E. Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages. Nat Metab. 2020 Nov;2(11):1265-1283. doi: 10.1038\/s42255-020-00305-3. Epub 2020 Nov 16. PMID: 33199924<\/p><p>\u00a0<\/p><p>\u6587\u7ae0\u4f86\u6e90:<\/p><p>\u00a0<\/p><p>https:\/\/www.nmn.com\/news\/cd38-enzymes-on-immune-cells-drive-nad-decline-with-age<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u4e00\u9805\u91dd\u5c0d\u8001\u5e74\u7537\u6027\u7684\u81e8\u5e8a\u7814\u7a76\u9996\u6b21\u8868\u660e\uff0c\u670d\u7528 NMN \u6703\u589e\u52a0\u8840\u6db2 NAD+ \u6c34\u5e73\u4e26\u6539\u5584\u808c\u8089\u529b\u91cf\u548c\u6027\u80fd\u7684\u5404\u7a2e\u6307\u6a19\u3002 &#8230;<\/p>\n","protected":false},"author":1,"featured_media":9031,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[180],"tags":[],"class_list":["post-9029","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-180","nt-post-class","","excerpt-none"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-08-02 16:54:45","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"rttpg_featured_image_url":{"full":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/829637_400119.jpg",1116,678,false],"landscape":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/829637_400119.jpg",1116,678,false],"portraits":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/829637_400119.jpg",1116,678,false],"thumbnail":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/829637_400119-150x150.jpg",150,150,true],"medium":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/829637_400119-300x182.jpg",300,182,true],"large":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/829637_400119-1024x622.jpg",960,583,true],"1536x1536":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/829637_400119.jpg",1116,678,false],"2048x2048":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/829637_400119.jpg",1116,678,false],"trp-custom-language-flag":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/829637_400119.jpg",18,12,false],"goldsmith-quickview":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/829637_400119.jpg",60,36,false],"goldsmith-panel":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/829637_400119.jpg",80,49,false],"goldsmith-mini":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/829637_400119.jpg",300,182,false],"goldsmith-medium":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/829637_400119.jpg",370,225,false],"goldsmith-square":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/829637_400119.jpg",500,304,false],"goldsmith-grid":["https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/829637_400119.jpg",767,466,false]},"rttpg_author":{"display_name":"nkcomys","author_link":"https:\/\/cytologics.com\/tc\/author\/nkcomys\/"},"rttpg_comment":0,"rttpg_category":"<a href=\"https:\/\/cytologics.com\/tc\/%e7%a7%91%e7%a0%94%e8%b3%87%e8%a8%8a\/\" rel=\"category tag\">\u79d1\u7814\u8cc7\u8a0a<\/a>","rttpg_excerpt":"\u4e00\u9805\u91dd\u5c0d\u8001\u5e74\u7537\u6027\u7684\u81e8\u5e8a\u7814\u7a76\u9996\u6b21\u8868\u660e\uff0c\u670d\u7528 NMN \u6703\u589e\u52a0\u8840\u6db2 NAD+ \u6c34\u5e73\u4e26\u6539\u5584\u808c\u8089\u529b\u91cf\u548c\u6027\u80fd\u7684\u5404\u7a2e\u6307\u6a19\u3002 ...","_links":{"self":[{"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/posts\/9029","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/comments?post=9029"}],"version-history":[{"count":8,"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/posts\/9029\/revisions"}],"predecessor-version":[{"id":17312,"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/posts\/9029\/revisions\/17312"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/media\/9031"}],"wp:attachment":[{"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/media?parent=9029"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/categories?post=9029"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cytologics.com\/tc\/wp-json\/wp\/v2\/tags?post=9029"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}