{"id":9354,"date":"2020-10-01T23:32:14","date_gmt":"2020-10-01T15:32:14","guid":{"rendered":"https:\/\/www.cytologics.com.hk\/?p=9354"},"modified":"2024-03-15T16:17:09","modified_gmt":"2024-03-15T08:17:09","slug":"%e5%8f%b2%e4%b8%8a%e6%9c%80%e5%ae%8c%e6%95%b4nad%e5%85%a8%e4%bb%8b%e7%b4%b9","status":"publish","type":"post","link":"https:\/\/cytologics.com\/tc\/%e5%8f%b2%e4%b8%8a%e6%9c%80%e5%ae%8c%e6%95%b4nad%e5%85%a8%e4%bb%8b%e7%b4%b9\/","title":{"rendered":"\u53f2\u4e0a\u6700\u5b8c\u6574NAD+\u5168\u4ecb\u7d39"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"9354\" class=\"elementor elementor-9354\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"gap-default elementor-section elementor-top-section elementor-element elementor-element-27c3e5a6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"27c3e5a6\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container 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\u9019\u4e9b\u7dad\u751f\u7d20\u5305\u62ec\u7159\u9170\u80fa(NAM)\u3001\u83f8\u9178(NA)\u3001\u7159\u9170\u80fa\u55ae\u6838\u82f7\u9178\uff08NMN\uff09\u548c\u7159\u9170\u80fa\u6838\u7cd6\u82f7\uff08NR\uff09\uff0c\u83f8\u9178\u901a\u904e\u4e09\u500b\u6b65\u9a5f\u8f49\u5316\u70baNAD +\u3002 \u7b2c\u4e00\u6b65\uff0cNAPRT\u9176\u5c07\u83f8\u9178\u8f49\u5316\u70ba\u83f8\u9178\u55ae\u6838\u82f7\u9178\uff08NAMN\uff09\u3002 \u5728\u7b2c\u4e8c\u6b65\u4e2d\uff0c\u9176NMNAT\u5c07NAMN\u8f49\u63db\u70ba\u83f8\u9178\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178\uff08NAAD\uff09\u3002 \u7136\u5f8c\uff0cNAD +\u5408\u6210\u9176\uff08NADS\uff09\u9176\u5c07NAAD\u8f49\u5316\u70baNAD +\u3002<\/p><p>\u00a0<\/p><p>\u88dc\u6551\u9014\u5f91\u4e2d\u7684NAD +\u751f\u7269\u5408\u6210\u6d89\u53ca\u7159\u9170\u80fa\u901a\u904e\u78f7\u9178\u6838\u7cd6\u57fa\u8f49\u79fb\u9176NMNAT\u8f49\u5316\u70baNMN\u3002 \u9019\u7a2e\u9176\u5c07NMN\u8f49\u5316\u70baNAD +\u3002<\/p><p>\u00a0<\/p><p>NR\u5728\u9176NRK\u7684\u4f5c\u7528\u4e0b\u8f49\u5316\u70baNMN\u3002 NMN\u901a\u904eNMNAT\u7684\u9176\u4fc3\u6d3b\u6027\u8f49\u5316\u70baNAD +\u3002<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4c181cd elementor-widget elementor-widget-image\" data-id=\"4c181cd\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"632\" src=\"https:\/\/cytologics.com\/wp-content\/uploads\/2022\/04\/444511_136078.jpg\" class=\"attachment-full size-full wp-image-9335\" alt=\"NMN VS NR\uff1a\u9019\u5169\u7a2e NAD+ \u524d\u9ad4\u4e4b\u9593\u7684\u5dee\u7570\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-715b6a5 elementor-widget elementor-widget-text-editor\" data-id=\"715b6a5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>\u5b83\u662f\u4ec0\u9ebc\u505a\u7684\uff1f<\/h3><p>\u00a0<\/p><p>NAD +\u7531\u901a\u904e\u78f7\u9178\u57fa\u5718\u9023\u63a5\u7684\u5169\u500b\u6838\u82f7\u9178\u7d44\u6210\u3002 \u4e00\u500b\u6838\u82f7\u9178\u5305\u542b\u817a\u560c\u5464\u6838\u82f7\u9e7c\u57fa\uff0c\u53e6\u4e00\u500b\u6838\u82f7\u9178\u5305\u542b\u7159\u9170\u80fa\u3002<\/p><p>\u00a0<\/p><h3>NAD+\u751f\u7269\u5408\u6210\u7684\u524d\u9ad4<\/h3>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a4cfe8e elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"a4cfe8e\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img loading=\"lazy\" decoding=\"async\" width=\"680\" height=\"128\" src=\"https:\/\/cytologics.com\/wp-content\/uploads\/2020\/10\/575905_445397.jpg\" class=\"attachment-full size-full wp-image-9359\" alt=\"\u53f2\u4e0a\u6700\u5b8c\u6574NAD+\u5168\u4ecb\u7d39\" \/><\/figure><div class=\"elementor-image-box-content\"><p class=\"elementor-image-box-description\">Braidy et al. (2019). Chemical structures of NAD+ precursors\n<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8590598 elementor-widget elementor-widget-text-editor\" data-id=\"8590598\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>NAD +\u524d\u9ad4\u88dc\u5145\u5291\u4ee3\u8868\u4e86\u4e00\u7a2e\u6f5b\u5728\u7684\u6cbb\u7642\u7b56\u7565\uff0c\u53ef\u4ee5\u6e1b\u7de9\u8870\u8001\u4e26\u6539\u5584\u8207\u5e74\u9f61\u6709\u95dc\u7684\u75be\u75c5\u3002\u76ee\u524d\u5c1a\u672a\u8b49\u660e\u53e3\u670dNAD +\u53ef\u4ee5\u589e\u52a0\u9ad4\u5167NAD +\u7684\u6c34\u5e73\u3002 \u4f46\u662f\uff0c\u88dc\u5145\u524d\u9ad4\uff08\u4f8b\u5982NMN\u6216NR\uff09\u53ef\u80fd\u6703\u63d0\u4f9b\u9019\u4e9b\u76ca\u8655\u3002<\/p><p>\u00a0<\/p><p>\u7814\u7a76\u986f\u793a\uff0c\u88dc\u5145NMN\u53ef\u4ee5\u9810\u9632\u5404\u7a2e\u75be\u75c5\u3002\u9019\u7a2e\u6548\u61c9\u53ef\u80fd\u662f\u901a\u904e\u63d0\u5347\u9ad4\u5167NAD+\u6c34\u5e73\u800c\u7522\u751f\u7684\u3002\u88dc\u5145NMN\u53ef\u4ee5\u51cf\u5c11\u80a5\u80d6\u3001\u4fdd\u8b77\u8840\u7ba1\u514d\u53d7\u640d\u50b7\u3002\u9019\u4e9b\u76ca\u8655\u4f86\u81ea\u65bc\u963f\u8328\u6d77\u9ed8\u75c7\u3001\u8a8d\u77e5\u969c\u7919\u548c\u795e\u7d93\u708e\u75c7\u7684\u5c0f\u9f20\u75be\u75c5\u6a21\u578b\u3002\u88dc\u5145NR\u5c0d\u5c0f\u9f20\u4e5f\u6709\u985e\u4f3c\u7684\u6709\u76ca\u6548\u679c\u3002<\/p><p>\u00a0<\/p><p>\u9019\u4e9b\u5c0d\u5c0f\u9f20\u7684\u6709\u76ca\u5f71\u97ff\u80fd\u61c9\u7528\u65bc\u4eba\u985e\u55ce\uff1f \u53ea\u6709\u5728\u4eba\u9ad4\u4e2d\u9032\u884c\u7684\u81e8\u5e8a\u8a66\u9a57\u624d\u80fd\u8b49\u660e\u9019\u4e00\u9ede\u3002<\/p><p>\u00a0<\/p><p>\u5728\u8870\u8001\uff0cNMN\u6216NR\u671f\u9593\uff0c\u54ea\u7a2e\u524d\u9ad4\u88dc\u5145\u5291\u53ef\u4fc3\u9032\u9ad4\u5167\u66f4\u9ad8\u6c34\u5e73\u7684NAD +\uff1f \u79d1\u5b78\u5bb6\u4e4b\u9593\u7684\u8faf\u8ad6\u4ecd\u5728\u7e7c\u7e8c\u3002<\/p><p>\u00a0<\/p><h3>NAD+\u662f\u8f14\u9176\u9084\u662f\u8f14\u56e0\u5b50\uff1f<\/h3><p>\u00a0<\/p><p>NAD +\u662f\u8f14\u56e0\u5b50\u548c\u8f14\u9176\u3002 \u8f14\u56e0\u5b50\u662f\u9176\u52a0\u901f\u53cd\u61c9\u6240\u9700\u7684\u975e\u86cb\u767d\u8cea\u5316\u5408\u7269\u3002 \u8f14\u52a9\u56e0\u5b50\u662f\u201c\u8f14\u52a9\u5206\u5b50\u201d\uff0c\u6709\u52a9\u65bc\u751f\u5316\u8f49\u5316\u3002<\/p><p>\u00a0<\/p><p>NAD +\u5728\u65b0\u9673\u4ee3\u8b1d\u7684\u96fb\u5b50\u8f49\u79fb\u53cd\u61c9\u4e2d\u8d77\u8f14\u52a9\u56e0\u5b50\u7684\u4f5c\u7528\u3002 \u4f46\u662f\uff0cNAD +\u5728\u8207\u7a31\u70baSirtuins\u7684\u86cb\u767d\u8cea\u7d50\u5408\u6642\u5145\u7576\u8f14\u9176\u3002 \u8a72\u5206\u5b50\u8207\u9019\u4e9b\u86cb\u767d\u8cea\u7d50\u5408\uff0c\u96a8\u5f8c\u91cb\u653e\u5b83\u5011\u4ee5\u4f9b\u9032\u4e00\u6b65\u4f7f\u7528\u3002<\/p><p>\u00a0<\/p><h3>NAD+\u7684\u6c34\u5e73\u964d\u4f4e\u6703\u767c\u751f\u4ec0\u9ebc\u4e8b\uff1f<\/h3><p>\u00a0<\/p><p>\u5927\u91cf\u7814\u7a76\u986f\u793a\uff0c\u5728\u71df\u990a\u5931\u8abf\u7684\u60c5\u6cc1\u4e0b\uff08\u4f8b\u5982\u80a5\u80d6\u75c7\u548c\u8870\u8001\uff09\uff0cNAD +\u7684\u6c34\u5e73\u6703\u964d\u4f4e\u3002 NAD +\u7684\u6c34\u5e73\u964d\u4f4e\u6703\u5c0e\u81f4\u65b0\u9673\u4ee3\u8b1d\u554f\u984c\u3002 \u9019\u4e9b\u554f\u984c\u53ef\u80fd\u5c0e\u81f4\u75be\u75c5\uff0c\u5305\u62ec\u80a5\u80d6\u548c\u80f0\u5cf6\u7d20\u62b5\u6297\u3002 \u80a5\u80d6\u6703\u5c0e\u81f4\u7cd6\u5c3f\u75c5\u548c\u9ad8\u8840\u58d3\u3002<\/p><p>\u00a0<\/p><p>\u4f4eNAD+\u6c34\u5e73\u6703\u5f15\u767c\u4ee3\u8b1d\u7d0a\u4e82\uff0c\u9ad8\u8840\u58d3\u548c\u5176\u4ed6\u5fc3\u81df\u529f\u80fd\u4e0b\u964d\u6703\u5411\u5927\u8166\u767c\u9001\u7834\u58de\u6027\u7684\u58d3\u529b\u6ce2\uff0c\u5f9e\u800c\u5c0e\u81f4\u8a8d\u77e5\u969c\u7919\u3002<\/p><p>\u00a0<\/p><p>\u4ee5NAD+\u4ee3\u8b1d\u70ba\u9776\u9ede\u662f\u9810\u9632\u4ee3\u8b1d\u6027\u75be\u75c5\u548c\u5176\u4ed6\u5e74\u9f61\u76f8\u95dc\u75be\u75c5\u7684\u5be6\u7528\u71df\u990a\u4ecb\u5165\u63aa\u65bd\u3002\u6709\u597d\u4e9b\u7814\u7a76\u986f\u793a\uff0c\u88dc\u5145NAD+\u88dc\u5145\u5291\u53ef\u4ee5\u6539\u5584\u80a5\u80d6\u5f15\u8d77\u7684\u80f0\u5cf6\u7d20\u62b5\u6297\u3002\u5728\u5e74\u9f61\u76f8\u95dc\u75be\u75c5\u7684\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u88dc\u5145NAD+\u88dc\u5145\u5291\u53ef\u6539\u5584\u75be\u75c5\u75c7\u72c0\u3002\u9019\u986f\u793a\u96a8\u8457\u5e74\u9f61\u7684\u589e\u9577\uff0cNAD+\u7684\u6c34\u5e73\u964d\u4f4e\u53ef\u80fd\u5c0e\u81f4\u5e74\u9f61\u76f8\u95dc\u75be\u75c5\u7684\u767c\u751f\u3002<\/p><p>\u00a0<\/p><p>\u9810\u9632NAD +\u7684\u4e0b\u964d\u70ba\u5c0d\u6297\u65b0\u9673\u4ee3\u8b1d\u7d0a\u4e82\u63d0\u4f9b\u4e86\u4e00\u7a2e\u6709\u5e0c\u671b\u7684\u7b56\u7565\u3002 \u7531\u65bcNAD +\u7684\u6c34\u5e73\u96a8\u8457\u5e74\u9f61\u7684\u589e\u9577\u800c\u964d\u4f4e\uff0c\u9019\u53ef\u80fd\u5c0e\u81f4DNA\u4fee\u5fa9\u3001\u7d30\u80de\u61c9\u6fc0\u53cd\u61c9\u548c\u80fd\u91cf\u4ee3\u8b1d\u8abf\u7bc0\u964d\u4f4e\u3002<\/p><p>\u00a0<\/p><h3>\u6f5b\u5728\u7684\u76ca\u8655<\/h3><p>\u00a0<\/p><p>NAD +\u5c0d\u65bc\u751f\u7269\u7684\u7c92\u7dda\u9ad4\u7dad\u6301\u548c\u6709\u95dc\u8870\u8001\u7684\u57fa\u56e0\u8abf\u63a7\u975e\u5e38\u91cd\u8981\u3002 \u4f46\u662f\uff0c\u96a8\u8457\u5e74\u9f61\u7684\u589e\u9577\uff0c\u6211\u5011\u9ad4\u5167\u7684NAD +\u542b\u91cf\u6703\u6025\u5287\u4e0b\u964d\u3002 \u201c\u96a8\u8457\u5e74\u9f61\u7684\u589e\u9577\uff0c\u6211\u5011\u6703\u5931\u53bbNAD +\u3002 \u523050\u6b72\u6642\uff0c\u60a8\u7684\u6c34\u5e73\u5df2\u7d93\u662f20\u6b72\u6642\u7684\u4e00\u534a\u5de6\u53f3\u3002\u201d\u54c8\u4f5b\u5927\u5b78\u7684\u5927\u885b\u00b7\u8f9b\u514b\u840a\u723e\u6559\u6388\uff08Prof. David Sinclair\uff09\u5728\u63a5\u53d7\u91c7\u8a2a\u6642\u8aaa\u3002<\/p><p>\u00a0<\/p><p>\u7814\u7a76\u986f\u793a\uff0cNAD+\u7684\u6e1b\u5c11\u8207\u8207\u5e74\u9f61\u6709\u95dc\u7684\u75be\u75c5\u6709\u95dc\uff0c\u5305\u62ec\u52a0\u901f\u8870\u8001\u3001\u4ee3\u8b1d\u7d0a\u4e82\u3001\u5fc3\u9ad2\u75c5\u548c\u795e\u7d93\u9000\u884c\u6027\u75be\u75c5\u3002 NAD+ \u6c34\u5e73\u7684\u964d\u4f4e\u8207\u5e74\u9f61\u76f8\u95dc\u7684\u75be\u75c5\u6709\u95dc\uff0c\u9019\u662f\u7531\u65bc\u529f\u80fd\u6027\u65b0\u9673\u4ee3\u8b1d\u8f03\u5c11\u6240\u81f4\u3002 \u4f46\u662f\u88dc\u5145NAD +\u6c34\u5e73\u5df2\u5728\u52d5\u7269\u6a21\u578b\u4e2d\u8868\u73fe\u51fa\u6297\u8870\u8001\u4f5c\u7528\uff0c\u5728\u9006\u8f49\u8207\u5e74\u9f61\u6709\u95dc\u7684\u75be\u75c5\u3001\u5ef6\u9577\u58fd\u547d\u548c\u5065\u5eb7\u65b9\u9762\u986f\u793a\u51fa\u4ee4\u4eba\u632f\u596e\u7684\u7d50\u679c\u3002<\/p><p>\u00a0<\/p><h3>\u8870\u8001<\/h3><p>\u00a0<\/p><p>Sirtuins\u88ab\u7a31\u70ba\u201c\u57fa\u56e0\u7d44\u7684\u5b88\u8b77\u8005\u201d\uff0c\u9019\u4e9b\u57fa\u56e0\u53ef\u4ee5\u4fdd\u8b77\u751f\u7269\u9ad4\uff08\u5f9e\u690d\u7269\u5230\u54fa\u4e73\u52d5\u7269\uff09\u514d\u65bc\u9000\u5316\u548c\u75be\u75c5\u4fb5\u8972\u3002 \u7576\u57fa\u56e0\u611f\u89ba\u5230\u8eab\u9ad4\u8655\u65bc\u8eab\u9ad4\u58d3\u529b\u4e0b\u6642\uff0c\u4f8b\u5982\u904b\u52d5\u6216\u98e2\u9913\uff0c\u5b83\u6703\u6d3e\u51fa\u90e8\u968a\u4f86\u634d\u885b\u8eab\u9ad4\u3002 Sirtuins\u53ef\u4ee5\u7dad\u6301\u57fa\u56e0\u7d44\u5b8c\u6574\u6027\uff0c\u4fc3\u9032DNA\u4fee\u5fa9\uff0c\u4e26\u5728\u6a21\u578b\u52d5\u7269\u4e2d\u986f\u793a\u51fa\u8207\u8870\u8001\u76f8\u95dc\u7684\u7279\u6027\uff0c\u4f8b\u5982\u5ef6\u9577\u58fd\u547d\u3002<\/p><p>\u00a0<\/p><p>NAD +\u662f\u9a45\u52d5\u57fa\u56e0\u767c\u63ee\u4f5c\u7528\u7684\u71c3\u6599\u3002 \u4f46\u662f\u5c31\u50cf\u6c7d\u8eca\u4e0d\u80fd\u6c92\u6709\u71c3\u6599\u5c31\u7121\u6cd5\u99d5\u99db\u4e00\u6a23\uff0cSirtuins\u9700\u8981NAD +\u624d\u80fd\u904b\u4f5c\u3002 \u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u63d0\u9ad8\u9ad4\u5167NAD\u7684 +\u6c34\u5e73\u53ef\u6fc0\u6d3b\u6c89\u9ed8\u8abf\u7bc0\u86cb\u767d\uff0c\u4e26\u5ef6\u9577\u9175\u6bcd\u3001\u8815\u87f2\u548c\u5c0f\u9f20\u7684\u58fd\u547d\u3002 \u5118\u7ba1\u88dc\u5145NAD +\u5728\u52d5\u7269\u6a21\u578b\u4e2d\u986f\u793a\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u7d50\u679c\uff0c\u4f46\u79d1\u5b78\u5bb6\u4ecd\u5728\u7814\u7a76\u9019\u4e9b\u7d50\u679c\u5982\u4f55\u8f49\u5316\u70ba\u4eba\u985e\u3002<\/p><p>\u00a0<\/p><h3>\u808c\u8089\u529f\u80fd<\/h3><p>\u00a0<\/p><p>\u7c92\u7dda\u9ad4\u4f5c\u70ba\u4eba\u9ad4\u7684\u52d5\u529b\u6e90\uff0c\u5c0d\u65bc\u6211\u5011\u7684\u904b\u52d5\u8868\u73fe\u81f3\u95dc\u91cd\u8981\u3002 NAD +\u662f\u7dad\u6301\u5065\u5eb7\u7684\u7dda\u7c92\u9ad4\u548c\u7a69\u5b9a\u80fd\u91cf\u8f38\u51fa\u7684\u95dc\u9375\u4e4b\u4e00\u3002<\/p><p>\u00a0<\/p><p>\u808c\u8089\u4e2dNAD +\u542b\u91cf\u7684\u589e\u52a0\u53ef\u4ee5\u6539\u5584\u5c0f\u9f20\u7684\u7c92\u7dda\u9ad4\u548c\u9ad4\u8cea\u3002 \u5176\u4ed6\u7814\u7a76\u4e5f\u986f\u793a\uff0c\u4f7f\u7528NAD 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\u7814\u7a76\u986f\u793a\uff0c\u5373\u4f7f\u5728\u8001\u5e74\u5c0f\u9f20\u4e2d\uff0c\u670d\u7528NAD +\u88dc\u5145\u5291\u4e5f\u53ef\u4ee5\u6e1b\u8f15\u8207\u98f2\u98df\u6709\u95dc\u548c\u8207\u5e74\u9f61\u6709\u95dc\u7684\u9ad4\u91cd\u589e\u52a0\uff0c\u4e26\u63d0\u9ad8\u5176\u904b\u52d5\u80fd\u529b\u3002 \u5176\u4ed6\u7814\u7a76\u751a\u81f3\u9006\u8f49\u4e86\u96cc\u6027\u5c0f\u9f20\u7684\u7cd6\u5c3f\u75c5\u6548\u61c9\uff0c\u986f\u793a\u4e86\u5c0d\u6297\u4ee3\u8b1d\u7d0a\u4e82\u7684\u65b0\u7b56\u7565\u3002<\/p><p>\u00a0<\/p><h3>\u4ee3\u8b1d\u75be\u75c5<\/h3><p>\u00a0<\/p><p>\u80a5\u80d6\u75c7\u88ab\u4e16\u754c\u885b\u751f\u7d44\u7e54\uff08WHO\uff09\u5ba3\u4f48\u70ba\u6d41\u884c\u75c5\uff0c\u662f\u73fe\u4ee3\u793e\u6703\u4e2d\u6700\u5e38\u898b\u7684\u75be\u75c5\u4e4b\u4e00\u3002 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\u5982\u679c\u60a8\u662f\u8001\u9f20\u3002 \u7528\u88dc\u5145\u5291\uff08\u4f8b\u5982NMN\u548cNR\uff09\u589e\u52a0NAD +\u53ef\u4ee5\u5ef6\u9577\u5c0f\u9f20\u7684\u58fd\u547d\u548c\u5065\u5eb7\u58fd\u547d\u3002<\/p><p>\u00a0<\/p><p>\u5347\u9ad8NAD +\u7684\u6c34\u5e73\u5728\u5ef6\u9577\u5c0f\u9f20\u7684\u58fd\u547d\u4e2d\u8d77\u9069\u5ea6\u7684\u4f5c\u7528\u3002 \u79d1\u5b78\u5bb6\u57282016\u5e74\u9802\u7d1a\u5b78\u8853\u671f\u520a\u300a\u79d1\u5b78\u300b(Science)\u4e0a\u767c\u8868\u7684\u4e00\u9805\u7814\u7a76\u4e2d\u767c\u73fe\uff0c\u4f7f\u7528NAD +\u524d\u9ad4NR\u53ef\u4ee5\u4f7f\u5c0f\u9f20\u7684\u58fd\u547d\u5ef6\u9577\u5927\u7d045\uff05\u3002<\/p><p>\u00a0<\/p><p>\u5347\u9ad8\u7684NAD +\u6c34\u5e73\u9084\u53ef\u4ee5\u9810\u9632\u5404\u7a2e\u8207\u5e74\u9f61\u6709\u95dc\u7684\u75be\u75c5\u3002 \u9810\u9632\u8207\u5e74\u9f61\u6709\u95dc\u7684\u75be\u75c5\u610f\u5473\u8457\u66f4\u9577\u58fd\u7684\u5065\u5eb7\u751f\u6d3b\uff0c\u589e\u52a0\u5065\u5eb7\u58fd\u547d\u3002<\/p><p>\u00a0<\/p><p>\u5be6\u969b\u4e0a\uff0c\u4e00\u4e9b\u50cfSinclair\u9019\u6a23\u7684\u6297\u8870\u8001\u79d1\u5b78\u5bb6\u8a8d\u70ba\uff0c\u4ed6\u5011\u81ea\u5df1\u670d\u7528\u4e86NAD +\u88dc\u5145\u5291\uff0c\u5f9e\u800c\u5728\u52d5\u7269\u7814\u7a76\u4e2d\u53d6\u5f97\u4e86\u6210\u529f\u3002 \u4f46\u662f\uff0c\u5176\u4ed6\u985e\u4f3c\u570b\u7acb\u885b\u751f\u7814\u7a76\u9662\u8870\u8001\u7814\u7a76\u6240\u7684\u8cbb\u5229\u4f69\u00b7\u585e\u62c9\uff08Felipe Sierra\uff09\u7684\u79d1\u5b78\u5bb6\u5247\u8a8d\u70ba\u8a72\u985e\u85e5\u7269\u5c1a\u672a\u6e96\u5099\u5c31\u7dd2\u3002 \u201c\u6700\u91cd\u8981\u7684\u662f\uff0c\u6211\u4e0d\u6703\u5617\u8a66\u4efb\u4f55\u9019\u4e9b\u65b9\u6cd5\u3002 \u6211\u70ba\u4ec0\u9ebc\u4e0d\u5462\uff1f \u56e0\u70ba\u6211\u4e0d\u662f\u8001\u9f20\uff0c\u201d\u4ed6\u8aaa\u3002<\/p><p>\u00a0<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9d2012f elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"9d2012f\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img loading=\"lazy\" decoding=\"async\" width=\"235\" height=\"160\" src=\"https:\/\/cytologics.com\/wp-content\/uploads\/2020\/10\/719942_389597.jpg\" class=\"attachment-full size-full wp-image-9360\" alt=\"\u53f2\u4e0a\u6700\u5b8c\u6574NAD+\u5168\u4ecb\u7d39\" \/><\/figure><div class=\"elementor-image-box-content\"><p class=\"elementor-image-box-description\">Zhang et al. (2016)\n<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-14594e9 elementor-widget elementor-widget-text-editor\" data-id=\"14594e9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u5c0d\u8001\u9f20\u4f86\u8aaa\uff0c\u201c\u9752\u5e74\u4e4b\u6cc9\u201d\u7684\u641c\u5c0b\u53ef\u80fd\u5df2\u7d93\u7d50\u675f\u3002 \u4f46\u662f\uff0c\u5c0d\u65bc\u4eba\u985e\u4f86\u8aaa\uff0c\u79d1\u5b78\u5bb6\u5011\u8a8d\u70ba\u6211\u5011\u9084\u6c92\u627e\u5230\u3002 NMN\u548cNR\u5728\u4eba\u9ad4\u4e2d\u7684\u81e8\u5e8a\u8a66\u9a57\u53ef\u80fd\u6703\u5728\u672a\u4f86\u5e7e\u5e74\u5167\u63d0\u4f9b\u7d50\u679c\u3002<\/p><p>\u00a0<\/p><h3>\u6211\u5011\u5982\u4f55\u63d0\u9ad8\u9ad4\u5167NAD+\u7684\u542b\u91cf<\/h3><p>\u00a0<\/p><p>\u53ef\u4ee5\u901a\u904e\u4fc3\u9032NAD +\u7684\u5408\u6210\u4f86\u63d0\u9ad8NAD +\u7684\u6c34\u5e73\uff0c\u5373\u589e\u5f37NAD 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